Xenglu Met 5+500mg Tablets Online At Best Price In Pakistan

GENERIC: Empagliflozin 5mg+Metformin HCl 500mg

MANUFACTURER: Hilton Pharma

QUANTITY:

14 Tablets per pack

INDICATION

Xenglu Met 5mg+500mg Tab is a lower-strength fixed-dose combination of empagliflozin and metformin indicated for the management of type 2 diabetes mellitus in adults as an adjunct to diet and exercise. This initiation-friendly formulation is suitable for patients transitioning from metformin monotherapy to dual therapy who require a gradual approach to minimize gastrointestinal intolerance, patients with mild to moderate hyperglycemia not requiring higher metformin doses at treatment initiation, and those beginning combination SGLT2 inhibitor and metformin therapy in a stepwise manner. The lower doses of both components make this the preferred starting point for many patients initiating dual therapy, with escalation to higher-strength combinations as tolerated and as glycemic targets require.

MECHANISM OF ACTION

Empagliflozin 12.5 mg inhibits SGLT2 in the kidneys, reducing glucose and sodium reabsorption and promoting urinary glucose excretion, which lowers both fasting and postprandial blood sugar without increasing insulin release, thus carrying a low risk of hypoglycemia. Its mild diuretic effect also helps reduce blood pressure and provides cardiovascular and renal protection. Metformin 1000 mg works by activating AMPK, significantly decreasing hepatic glucose production, and improving insulin sensitivity in peripheral tissues. Together, they offer complementary and synergistic glycemic control by targeting both renal glucose elimination and hepatic glucose overproduction.

DOSAGE AND ADMINISTRATION

•      Take one tablet twice daily with morning and evening meals.

•      Always take it with food to minimize gastrointestinal effects from the metformin component.

•      Swallow whole with a full glass of water; do not crush or split.

•      Escalation to higher-strength combinations can be made based on glycemic response and tolerability as directed by your physician.

•      Assess eGFR before initiating and monitor renal function periodically throughout treatment.

SIDE EFFECTS

•      Common: Genital mycotic infections, urinary tract infections, mild gastrointestinal discomfort during initiation, and increased urinary frequency.

•      Less common: Volume depletion symptoms, including dizziness and mild blood pressure reduction, headache, and nasopharyngitis.

NOT RECOMMENDED IN

Contraindicated in type 1 diabetes and diabetic ketoacidosis. Not for use in patients with eGFR below 45ml/min/1.73m², severe hepatic impairment, excessive alcohol consumption, decompensated heart failure, respiratory failure, or during pregnancy and breastfeeding. Withhold temporarily before iodinated contrast imaging and during acute serious illness with significant dehydration risk.

DRUG INTERACTIONS

Insulin and sulfonylureas increase the risk when combined with this product. Diuretics potentiate the volume-depleting effect of empagliflozin. Iodinated contrast procedures require metformin discontinuation at least 48 hours before and after. UGT inducers such as rifampicin may reduce empagliflozin exposure. Cationic drugs such as cimetidine may elevate metformin levels through competition for renal tubular secretion.

STORAGE INSTRUCTIONS

Store below 30°C in a cool, dry place away from moisture and direct sunlight. Keep in original blister packaging. Store out of reach of children. Do not use after the expiry date printed on the pack.

WHERE TO BUY

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