X-plended Ez 5/10mg Tablets Online At Best Price In Pakistan

GENERIC: Rosuvastatin 5mg+Ezetimibe 10mg

MANUFACTURER: PharmEvo

QUANTITY:

10 Tablets per pack

INDICATION

X-Plended EZ 5/10mg Tab is a fixed-dose combination lipid-lowering agent indicated for the treatment of primary hypercholesterolemia and mixed dyslipidemia in adults as an adjunct to diet when the response to statin monotherapy or ezetimibe monotherapy alone is inadequate. It is used to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B, non-HDL cholesterol, and triglycerides while increasing HDL cholesterol. This combination is particularly appropriate for patients who require significant LDL lowering to meet their cardiovascular risk targets but cannot tolerate or do not achieve adequate response with higher statin doses, as the dual mechanism of action provides additive LDL reduction with a lower statin dose and therefore a reduced risk of dose-dependent statin side effects.

MECHANISM OF ACTION

X-Plended EZ 5/10 mg combines two complementary lipid-lowering agents for enhanced efficacy. Rosuvastatin 5 mg inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis and increasing LDL receptor expression, which enhances clearance of LDL cholesterol from the bloodstream while also improving triglycerides and HDL levels. Ezetimibe 10 mg works by inhibiting the NPC1L1 transporter in the small intestine, decreasing absorption of dietary and biliary cholesterol. This further reduces cholesterol delivery to the liver and promotes additional upregulation of the LDL receptor. Together, these dual mechanisms provide greater LDL reduction than either agent alone by targeting both cholesterol production in the liver and absorption in the intestine.

DOSAGE AND ADMINISTRATION

•      Take one tablet once daily with or without food.

•      Take at the same time each day, preferably in the evening..

•      Lifestyle modifications, including a heart-healthy diet, regular physical activity, and smoking cessation, should be maintained throughout treatment.

•      Regular monitoring of lipid levels and liver function tests is recommended during therapy.

SIDE EFFECTS

•      Common: Headache, myalgia (muscle pain), nausea, abdominal discomfort, fatigue, constipation, or diarrhea.

•      Less common: Elevated hepatic transaminases, elevated creatine kinase (CK), dizziness, rash.

NOT RECOMMENDED IN

X-Plended EZ 5/10mg Tab is contraindicated in patients with active hepatic disease or persistently elevated serum transaminases exceeding 3 times the upper limit of normal. It is absolutely contraindicated during pregnancy due to the teratogenicity of statins, and in breastfeeding women. Contraindicated in patients with known hypersensitivity to rosuvastatin, ezetimibe, or any excipient. The combination should not be used with drugs known to cause rhabdomyolysis when combined with statins without careful dose assessment. Asian patients may require lower doses due to higher rosuvastatin plasma exposures.

DRUG INTERACTIONS

Cyclosporine significantly increases rosuvastatin plasma concentrations (by approximately 7-fold), and combined use is contraindicated or requires close monitoring with a 5mg statin dose maximum. Fenofibrate and niacin at lipid-lowering doses increase the risk of myopathy when combined with rosuvastatin. The warfarin anticoagulant effect may be enhanced by rosuvastatin; regular INR monitoring is required. Antacids containing aluminum and magnesium reduce ezetimibe plasma concentrations and should be separated by at least 2 hours. Bile acid sequestrants such as cholestyramine reduce ezetimibe absorption.

STORAGE INSTRUCTIONS

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep in original blister packaging. Store out of reach of children. Do not use after the expiry date printed on the pack.

WHERE TO BUY

Dawa Healthcare Pharmacy provides a reliable and professional platform for patients looking to buy X-Plended EZ 5/10mg Tab 10s online in Pakistan, with genuine rosuvastatin-ezetimibe combination available from a verified supply chain at competitive prices. Patients checking the X-Plended EZ 5/10mg tablets 10s price in Pakistan will find accurate and current pricing maintained at dawahealthcare.biz. Complete details on X-Plended EZ 5/10mg tab uses are available on our product page. Order online for same-day delivery anywhere in Karachi, with our nationwide courier service delivering to every city in Pakistan. Dawa Healthcare Pharmacy's WhatsApp helpline and multiple Karachi branches are available for medication support.