Vepridone 3mg Tablets Online At Best Price In Pakistan

GENERIC: Risperidone 3mg

MANUFACTURER: Genetics Pharma

QUANTITY:

20 Tablets per pack

INDICATION

Vepridone 3mg Tab is indicated for the treatment of schizophrenia in adults and adolescents, covering both the acute management of psychotic episodes and long-term relapse prevention. It is also used for acute manic and mixed episodes associated with bipolar I disorder as monotherapy or combined with a mood stabilizer. The 3mg dose represents the commonly used effective therapeutic dose for schizophrenia and is appropriate for patients who have been titrated up from lower doses and have demonstrated tolerability.

MECHANISM OF ACTION

Risperidone is an atypical antipsychotic that works by blocking dopamine D2 and serotonin 5-HT2A receptors. In schizophrenia, it reduces overactive dopamine in the mesolimbic pathway, relieving positive symptoms like hallucinations and delusions. At the same time, 5-HT2A blockade increases dopamine in the prefrontal cortex, improving negative symptoms such as social withdrawal and cognitive issues. Risperidone’s effects on alpha-1 adrenergic and H1 histamine receptors cause sedation and blood pressure changes. Its balanced serotonin-dopamine antagonism lowers the risk of movement-related side effects compared to typical antipsychotics.

DOSAGE AND ADMINISTRATION

•      Schizophrenia in adults: Usual therapeutic dose is 4 to 8mg per day; 3mg twice daily may be prescribed based on clinical response.

•      Bipolar mania: 2 to 6mg once daily, adjusted by 1mg increments as needed.

•      Take with or without food, at the same time each day.

•      Dose adjustments should be made gradually and only under physician supervision.

•      Avoid abrupt discontinuation; taper the dose slowly when stopping treatment.

SIDE EFFECTS

•      Common: Weight gain, somnolence, headache, increased appetite, fatigue, constipation.

•      Less common: Hyperprolactinemia (causing menstrual irregularities, galactorrhea, gynecomastia), dizziness,

NOT RECOMMENDED IN

Vepridone 3mg Tab is contraindicated in patients with known hypersensitivity to risperidone or paliperidone. It must be used with extreme caution in elderly patients with dementia-related psychosis, as antipsychotics in this population are associated with increased mortality from cardiovascular events and infection,s and such use is not approved. Caution is also required in patients with Parkinson's disease or Lewy body dementia, cardiovascular disease, a history of seizures, diabetes mellitus, and conditions predisposing to QT prolongation.

DRUG INTERACTIONS

Carbamazepine and other CYP3A4 inducers significantly reduce risperidone plasma levels, potentially requiring dose increases; dose reduction is necessary if the inducer is discontinued. Fluoxetine and paroxetine increase risperidone concentrations. Concurrent use with other CNS depressants, including benzodiazepines and opioids, increases the risk of sedation and respiratory depression. QT-prolonging agents such as amiodarone, sotalol, and certain antipsychotics may have additive effects.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 25°C. Protect from moisture, light, and heat. Keep in the original packaging. Store out of reach of children. Do not use after the expiry date on the pack.

WHERE TO BUY

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