Valtec-amh 10+160+12.5mg Tablets Online At Best Price In Pakistan

GENERIC: Amlodipine 10 mg + Valsartan 160 mg + Hydrochlorothiazide 12.5 mg

MANUFACTURER: Tabros Pharma

QUANTITY:

28 Tablets per pack

INDICATION

Valtec-AMH 10+160+12.5mg Tab is a triple fixed-dose combination antihypertensive indicated for the management of hypertension in adults whose blood pressure cannot be adequately controlled on a dual-combination regimen. It is designed for patients who require three mechanisms of action simultaneously to achieve target blood pressure goals. By combining a calcium channel blocker, an angiotensin receptor blocker, and a thiazide diuretic in a single daily tablet, Valtec-AMH simplifies the treatment regimen, improves patient adherence, and reduces the cardiovascular and renal risks associated with poorly controlled hypertension.

MECHANISM OF ACTION

Valtec-AMH achieves blood pressure reduction through three distinct and complementary pathways. Amlodipine, a calcium channel blocker, relaxes the smooth muscle cells of peripheral blood vessels by blocking calcium ion entry, reducing vascular resistance and lowering systolic and diastolic pressure. Valsartan, an angiotensin II receptor blocker, prevents angiotensin II from binding to its AT1 receptor on blood vessels and the adrenal cortex, inhibiting vasoconstriction and aldosterone-mediated sodium and water retention. Hydrochlorothiazide is a thiazide diuretic that acts on the distal convoluted tubule of the kidney to inhibit sodium and chloride reabsorption, increasing urinary excretion of salt and water and thereby reducing blood volume and cardiac preload. The combined action of all three agents provides a powerful, well-tolerated, and sustained reduction in blood pressure across the 24-hour dosing interval.

DOSAGE AND ADMINISTRATION

•      Take one tablet orally once daily, preferably at the same time each day.

•      May be taken with or without food.

•      Swallow whole with a full glass of water; do not split, crush, or chew.

•      Regular blood pressure monitoring is recommended during treatment.

•      Do not stop taking this medication abruptly without medical advice.

SIDE EFFECTS

•      Common: Peripheral edema, dizziness, headache, increased urination, fatigue.

•      Less common: Electrolyte imbalances (low potassium, low sodium), muscle cramps, nausea, flushing.

•      Rare: Hypotension, hyperuricemia, elevated blood glucose, impaired renal function.

NOT RECOMMENDED IN

Valtec-AMH is contraindicated in pregnancy, particularly the second and third trimesters, due to the risk of fetal renal impairment and neonatal complications from ARB exposure. It must not be used in patients with anuria or severe renal impairment, severe hepatic impairment or biliary obstruction, or known hypersensitivity to sulfonamide-derived drugs (which includes hydrochlorothiazide). Concomitant use with aliskiren is contraindicated in diabetic patients. Patients with symptomatic hyperuricemia or gout should use this combination with caution.

DRUG INTERACTIONS

Concurrent use with other antihypertensives, nitrates, or vasodilators may produce additive hypotension. Potassium-depleting effects of hydrochlorothiazide are worsened by corticosteroids, ACTH, and amphotericin B, increasing the risk of hypokalemia. Hypokalemia induced by this combination increases the cardiotoxic risk of digoxin and requires close monitoring. NSAIDs may blunt the diuretic and antihypertensive effects. Lithium clearance is reduced by thiazide diuretics, increasing toxicity risk. Iodinated contrast agents used in radiology may precipitate acute kidney injury in patients on this regimen.

STORAGE INSTRUCTIONS

Store below 30°C in a dry environment, away from moisture, heat, and direct sunlight. Keep the tablets in their original blister pack until use. Store out of reach of children. Do not use beyond the expiry date printed on the packaging.

WHERE TO BUY

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