Sitaglu Met Xr 50/1000mg 28S Tablets Online At Best Price In Pakistan

Generic: Sitagliptin 50mg + Metformin HCl 1000mg (Extended Release)

Manufacturer: Hilton Pharma

Quantity:

28 Tablets per pack

INDICATION

Sitaglu Met XR 50/1000mg Tab is an extended-release combination antidiabetic tablet prescribed for the management of type 2 diabetes mellitus in adults who require a higher metformin dose for adequate glycemic control. The extended-release formulation ensures a slower, more gradual release of metformin throughout the day, significantly reducing gastrointestinal side effects while maintaining steady plasma levels. It is indicated when blood sugar remains inadequately controlled on lower-dose combination therapy or when patients need a once-daily regimen to improve long-term adherence to diabetes treatment alongside diet and exercise.

MECHANISM OF ACTION

Sitagliptin works by inhibiting the DPP-4 enzyme, which breaks down incretin hormones such as GLP-1. When these incretins are preserved, the pancreas responds by producing more insulin, specifically when blood glucose is elevated, and the liver reduces unnecessary glucose output. This mechanism is glucose-dependent, making hypoglycemia rare. Metformin XR works by reducing hepatic glucose production, improving peripheral insulin sensitivity, and decreasing intestinal absorption of glucose. The extended-release technology allows metformin to be absorbed gradually in the lower gastrointestinal tract, improving tolerability while maintaining effective blood sugar control throughout the day.

DOSAGE AND ADMINISTRATION

•      Usual dose: One tablet (50mg/1000mg) once daily with the evening meal.

•      Swallow whole with water; do not crush, break, or chew extended-release tablets.

•      Dose adjustments should be made by the physician based on HbA1c monitoring and renal function.

•      Take at the same time each evening to ensure consistent drug levels.

SIDE EFFECTS

•      Common: Mild nausea, diarrhea, abdominal discomfort (significantly less than immediate-release metformin), headache.

•      Less common: Pancreatitis (rare), upper respiratory infection, hypoglycemia with concurrent insulin or sulfonylureas, lactic acidosis (very rare).

NOT RECOMMENDED IN

Sitaglu Met XR 50/1000mg Tab is contraindicated in severe renal impairment (eGFR below 30 mL/min), metabolic acidosis, and type 1 diabetes. It should be withheld before contrast-based imaging procedures and resumed 48 hours after, provided renal function is confirmed as normal. It is not indicated in patients with liver disease or hypersensitivity to sitagliptin or metformin. Patients with a history of pancreatitis should be monitored closely.

DRUG INTERACTIONS

Iodinated contrast agents used in imaging can precipitate acute kidney injury, creating a risk of metformin accumulation and lactic acidosis; always pause metformin before such procedures. Alcohol significantly raises the risk of lactic acidosis. Sitagliptin combined with insulin or sulfonylureas increases the risk of hypoglycemia. Drugs that impair renal tubular secretion, such as cimetidine, can elevate metformin levels. Carbonic anhydrase inhibitors, including topiramate and acetazolamide, may increase the risk of metabolic acidosis.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 30°C. Protect from heat and moisture. Keep in original sealed packaging. Keep out of reach of children. Do not use after the expiry date on the carton.

WHERE TO BUY

Dawa Healthcare Pharmacy provides patients with a convenient and trustworthy avenue to buy Sitaglu Met XR 50/1000 Tab 28s online in Pakistan, ensuring a consistent supply of genuine diabetes medications. Those checking the Sitaglu Met XR 50/1000 tablets 28s price in Pakistan will find accurate pricing displayed on our website at all times. Order Sitaglu Met XR 50/1000 Tab online and receive same-day delivery within Karachi, while our reliable courier partnerships cover every city across Pakistan. Our accessible WhatsApp channel and widespread Karachi branches ensure professional pharmaceutical support is always within reach.