SEMMA 14MG TAB

Semma 14mg Tablets Online At Best Price In Pakistan

Generic: Semaglutide 14mg

Manufacturer: Horizon Pharmaceuticals

Quantity:

30 tablets per pack

INDICATION

Semma 14mg Tab is an oral GLP-1 receptor agonist used as an adjunct to diet and exercise for the improvement of glycemic control in adults with type 2 diabetes mellitus. It is indicated both as monotherapy when metformin is not tolerated and as an add-on to other antidiabetic agents when blood sugar remains inadequately controlled. At 14mg, this is the highest oral semaglutide dose used in patients who have been titrated up from 3mg and 7mg doses over time. It effectively lowers HbA1c, reduces fasting and postprandial blood glucose, supports body weight reduction, and may also reduce the risk of major adverse cardiovascular events.

MECHANISM OF ACTION

Semaglutide mimics a natural hormone called GLP-1 (glucagon-like peptide-1) that the gut releases after a meal. This hormone tells the pancreas to produce more insulin when blood sugar is high, reduces glucagon (a hormone that raises blood sugar), and slows how fast food leaves the stomach, making you feel fuller for longer. Semaglutide does all these things in a more potent and sustained way than the body's own GLP-1 because it resists enzymatic breakdown. The result is better blood sugar control, reduced appetite, and gradual weight loss.

DOSAGE AND ADMINISTRATION

•      Take one 14mg tablet once daily on an empty stomach, first thing in the morning.

•      Swallow with a small glass of water (approximately 120ml); do not use other beverages.

•      Wait at least 30 minutes before eating, drinking anything other than water, or taking other oral medications.

•      14mg is the maintenance dose; patients should have been previously titrated through 3mg and 7mg doses.

SIDE EFFECTS

•      Common: Nausea, vomiting, diarrhea, decreased appetite, abdominal discomfort.

•      Less common: Constipation, bloating, heartburn, fatigue, hypoglycemia when combined with insulin or sulfonylureas.

NOT RECOMMENDED IN

Semma 14mg Tab is not recommended in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN-2). It is not indicated for type 1 diabetes or diabetic ketoacidosis. Use with caution in patients with a history of pancreatitis; the drug should be discontinued if pancreatitis is confirmed. It is not recommended for patients with severe gastrointestinal disease.

DRUG INTERACTIONS

Semaglutide slows gastric emptying, which can affect the absorption rate and peak concentration of other orally administered medications. Co-administration with insulin or sulfonylureas significantly increases the risk of hypoglycemia; dose reductions of those agents may be required. DPP-IV inhibitors should generally not be combined with GLP-1 agonists due to overlapping mechanisms.

STORAGE INSTRUCTIONS

Store at room temperature below 30°C. Protect from moisture and light. Keep in original sealed packaging. Store out of reach of children. Do not use after the expiry date printed on the pack.

WHERE TO BUY

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