Savesto 49+51mg Tablets Online At Best Price In Pakistan

Generic: Sacubitril 49 mg + Valsartan 51 mg

Manufacturer: Getz Pharma

Quantity:

28 Tablets

INDICATION

Savesto 100 Tab is indicated for the treatment of symptomatic chronic heart failure with reduced ejection fraction (HFrEF) in adult patients. It is used to lower the risk of cardiovascular death and hospitalization due to heart failure complications. The 49mg/51mg strength serves as the standard recommended starting dose for most patients who are already stabilized on an ACE inhibitor or ARB therapy. Savesto 100 improves cardiac function, reduces fluid accumulation, relieves breathlessness and fatigue, and helps patients maintain a better quality of life over the long term when used as part of an individualized heart failure management plan.

MECHANISM OF ACTION

Savesto 100 works through the combined action of two complementary drugs. Sacubitril inhibits the enzyme neprilysin, preventing it from breaking down natriuretic peptides, which are the heart's own hormones that help regulate fluid balance and blood vessel tone. With more natriuretic peptides circulating, excess sodium and water are excreted, blood vessels relax, and the heart's workload decreases. Valsartan blocks angiotensin II receptors, stopping a potent vasoconstrictor hormone from tightening blood vessels and retaining sodium. Together, the two components create a comprehensive cardiac benefit through dual pathway inhibition.

DOSAGE AND ADMINISTRATION

•      Standard adult starting dose: One tablet (49mg/51mg) twice daily, taken orally.

•      Titrate to the target maintenance dose of 97mg/103mg twice daily after 2 to 4 weeks, as tolerated.

•      If switching from an ACE inhibitor, allow a 36-hour gap before initiating Savesto.

•      Doses should be taken approximately 12 hours apart each day.

SIDE EFFECTS

•      Common: Low blood pressure, elevated potassium, dizziness, renal impairment, and cough.

•      Less common: Angioedema (rare but serious), fatigue, headache, nausea.

NOT RECOMMENDED IN

Savesto 100 Tab is absolutely contraindicated with concurrent ACE inhibitor therapy. A 36-hour washout period is mandatory before switching from any ACE inhibitor to avoid potentially fatal angioedema. It is contraindicated during pregnancy due to the serious risk of fetal harm. It must not be used in patients with a history of ACE inhibitor-related angioedema or hereditary angioedema.

DRUG INTERACTIONS

Co-administration with ACE inhibitors is a strict contraindication. Potassium-raising drugs such as potassium-sparing diuretics, salt substitutes, or co-trimoxazole may worsen hyperkalemia. NSAIDs may impair kidney function and reduce antihypertensive effects. Sacubitril inhibits hepatic transporters OATP1B1 and OATP1B3, increasing concentrations of statin medications, which may increase the risk of myopathy. Lithium levels may rise when co-administered; regular monitoring is essential. All concurrent medications should be reviewed by the cardiologist before starting therapy.

STORAGE INSTRUCTIONS

Store at room temperature below 30°C. Keep away from sunlight and moisture. Store in original sealed packaging. Keep out of reach of children. Do not use beyond the expiry date printed on the carton.

WHERE TO BUY

Dawa Healthcare Pharmacy offers a trustworthy and convenient platform to buy Savesto 100 Tab 49+51mg 28s online in Pakistan, ensuring heart failure patients receive their medication reliably and on time. For those comparing the Savesto 100 tablets 49+51mg 28s price in Pakistan, our website presents transparent pricing with no hidden costs. Order Savesto 100 Tab online today and enjoy same-day delivery in Karachi, while patients in other cities benefit from our nationwide courier partnerships delivering across all of Pakistan. Reach us instantly on WhatsApp or visit our multiple Karachi branches for cardiac medication support.