Safepram 5mg Tablets Online At Best Price In Pakistan

Generic: Escitalopram 5mg

Manufacturer: Martin Dow Pharmaceuticals

Quantity:

14 Tablets per pack

INDICATION

Safepram 5mg Tab is an SSRI antidepressant indicated for the treatment of major depressive disorder and generalized anxiety disorder (GAD) in adults. The 5mg dose is commonly used as an introductory dose to minimize early side effects, particularly in elderly patients, those with hepatic impairment, or individuals who are sensitive to antidepressant therapy. It helps relieve persistent sadness, hopelessness, loss of interest in daily activities, excessive worry, irritability, and sleep disturbances. With consistent daily use, Safepram gradually restores emotional balance and improves overall mental well-being and functional capacity.

MECHANISM OF ACTION

Escitalopram is the most selective among all SSRIs, meaning it works very precisely on one specific target in the brain. It blocks the reabsorption of serotonin back into the nerve cells that released it. Serotonin is the brain's natural mood-regulating chemical, and when it is allowed to remain active in the space between brain cells for longer, it gradually restores emotional stability, reduces excessive worry, and improves mood. Because escitalopram targets only the serotonin transporter and almost nothing else, it tends to cause fewer side effects compared to older antidepressants.

DOSAGE AND ADMINISTRATION

•      Usual starting dose: 5mg once daily, taken orally with or without food.

•      Dose may be increased to 10mg once daily after one to two weeks based on clinical response.

•      Maximum recommended dose: 20mg once daily for adults.

•      Take at the same time each day, either in the morning or evening.

•      Do not stop abruptly; taper the dose gradually under physician supervision to prevent withdrawal symptoms.

SIDE EFFECTS

•      Common: Nausea, dry mouth, drowsiness, headache, insomnia, increased sweating.

•      Less common: Sexual dysfunction, dizziness, diarrhea, fatigue, tremor, palpitations.

NOT RECOMMENDED IN

Safepram 5mg Tab is contraindicated in patients currently taking or who have recently stopped monoamine oxidase inhibitors (MAOIs); allow a minimum 14-day gap. It must not be used with pimozide or other drugs that prolong the QT interval. It is not recommended in individuals with a known hypersensitivity to escitalopram or citalopram. Use with caution in patients with epilepsy, bipolar disorder, bleeding tendencies, or diabetes. Not recommended for children under 12 years, and pregnancy should be discussed thoroughly with the prescribing physician.

DRUG INTERACTIONS

The most critical interaction is with MAOIs, which can cause serotonin syndrome, a potentially fatal condition. Escitalopram must not be combined with linezolid, methylene blue, or other serotonergic drugs. Co-administration with NSAIDs, aspirin, or anticoagulants increases the risk of bleeding. Cimetidine, omeprazole, and other CYP2C19 inhibitors can raise escitalopram plasma levels significantly. Alcohol worsens CNS depression and should be avoided during treatment. Blood glucose regulation may be affected; diabetic patients require close monitoring during initiation or discontinuation of therapy.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 30°C. Protect from heat, moisture, and light. Keep in original blister packaging. Store out of reach of children and pets. Do not use after the expiry date on the packaging.

WHERE TO BUY

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