Roxudo 100mg Tablets Online At Best Price In Pakistan

Generic: Roxadustat 100mg

Manufacturer: CCL Pharmaceuticals

Quantity:

12 Tablets

INDICATION

Roxudo 100mg Tab is prescribed for the treatment of symptomatic anemia associated with chronic kidney disease (CKD) in adults, whether on dialysis or not. CKD-related anemia results from deficient erythropoietin production by the damaged kidneys, leading to low red blood cell counts, reduced hemoglobin, and debilitating fatigue. Roxudo stimulates the endogenous erythropoietin pathway, increases red blood cell production, and corrects iron dysregulation by suppressing hepcidin. It provides an orally administered alternative to injectable erythropoiesis-stimulating agents (ESAs), making it a more patient-friendly option for long-term CKD anemia management.

MECHANISM OF ACTION

Roxadustat in Roxudo acts by inhibiting the HIF prolyl hydroxylase enzyme, which normally marks HIF-alpha proteins for destruction when oxygen levels are normal. By inhibiting this enzyme, roxadustat prevents HIF-alpha degradation, allowing it to build up in cells. HIF-alpha then activates genes responsible for producing erythropoietin, which signals the bone marrow to increase red blood cell production. This process mimics the body's natural response to low oxygen levels, stimulating the production of more hemoglobin-rich red blood cells to improve oxygen delivery throughout the body.

DOSAGE AND ADMINISTRATION

•      Dosing is individualized and weight-based.

•      Hemoglobin levels must be monitored regularly; adjust dose as needed every four or more weeks to stay within the target range.

SIDE EFFECTS

•      Common: Hypertension, nausea, diarrhea, hyperkalemia, swelling in hands or feet.

•      Less common: Blood clot formation, dizziness, elevated cholesterol, vascular access thrombosis.

NOT RECOMMENDED IN

Roxudo 100mg Tab is not recommended in patients allergic to roxadustat or with decompensated liver disease. It requires caution in those with pre-existing cardiovascular risk factors, thrombotic history, or uncontrolled hypertension. Pregnancy should be avoided during treatment due to insufficient safety data. Breastfeeding is not advisable. Patients with severe hepatic impairment should only use this medication under close specialist supervision.

DRUG INTERACTIONS

Gemfibrozil should not be combined with roxadustat due to a significant pharmacokinetic interaction that raises drug levels substantially. Proton pump inhibitors and phosphate binders may reduce bioavailability if taken simultaneously. Concomitant use with statins that share OATP1B1 and OATP1B3 transporter pathways may alter statin exposure. Regular review of the patient's complete medication list is essential before and during roxadustat therapy to prevent clinically significant interactions.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 25°C. Protect from light, moisture, and excessive heat. Keep in original packaging. Store away from children. Do not use after the expiry date marked on the package.

WHERE TO BUY

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