Resmiron 80mg Tablets Online At Best Price In Pakistan

Generic: Resmetirom 80mg

Manufacturer: Getz Pharma

Quantity:

30 Tablets

INDICATION

Resmiron 80mg Tab is indicated for the treatment of non-alcoholic steatohepatitis (NASH) in adult patients with moderate to advanced liver fibrosis (stages F2 to F3), used in conjunction with diet and exercise. NASH is a progressive liver disease in which fat accumulates in the liver, causing inflammation and scarring. If left untreated, it can progress to cirrhosis and liver failure. Resmiron addresses the underlying metabolic dysfunction contributing to NASH, helping reduce liver inflammation, lower liver fat content, and slow the progression of fibrosis, thereby protecting long-term liver function and reducing the risk of serious complications.

MECHANISM OF ACTION

Resmetirom works by selectively targeting and activating the thyroid hormone receptor-beta (THR-beta) found primarily in the liver. This receptor plays a central role in regulating fat metabolism in liver cells. By activating THR-beta, resmetirom stimulates the breakdown of fats within the liver, reduces the production of new fat, and lowers liver triglyceride levels. This action directly addresses the excess fat accumulation that drives NASH-related inflammation and scarring, improving overall liver health without significantly affecting thyroid hormone levels in other organs.

DOSAGE AND ADMINISTRATION

•      For patients weighing less than 100kg: 80mg once daily, taken orally.

•      For patients weighing 100kg or more: 100mg once daily as prescribed.

•      Take at the same time each day and continue alongside a physician-recommended diet and exercise plan.

SIDE EFFECTS

•      Common: Diarrhea, nausea, vomiting, abdominal discomfort.

•      Less common: Dizziness, pruritus (itching), gallstones, elevated liver enzymes.

NOT RECOMMENDED IN

Resmiron 80mg Tab is not recommended in patients with decompensated cirrhosis or end-stage liver disease. It is contraindicated in those with known hypersensitivity to resmetirom. Patients with a history of gallbladder disease should be monitored carefully, as this drug may increase the risk of gallstones or gallbladder inflammation. Resmiron should not be used during pregnancy, as potential fetal risks are not fully established.

DRUG INTERACTIONS

Resmetirom may interact with statins, increasing the risk of muscle-related side effects such as myopathy. Patients on statin therapy should be monitored closely for muscle pain or weakness. Gemfibrozil and cyclosporine may significantly alter the plasma levels of resmetirom and should be avoided. Drugs that are substrates of hepatic transporters such as OATP1B1 and OATP1B3 may also be affected when co-administered. Patients should disclose all medications, supplements, and herbal products to their physician before starting treatment.

STORAGE INSTRUCTIONS

Store at room temperature between 20°C and 25°C. Protect from moisture and light. Keep in original packaging. Store out of reach of children. Do not use beyond the expiry date on the carton.

WHERE TO BUY

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