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GENERIC: Naproxen Sodium 500mg

MANUFACTURER: Martin Dow

QUANTITY:

Pack of 20 tablets

INDICATION

Proxen 500mg is a non-steroidal anti-inflammatory drug (NSAID) containing Naproxen Sodium, prescribed for the effective relief of pain, inflammation, and fever across a wide range of medical conditions. It is widely used in the management of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and gouty arthritis, providing both analgesic and anti-inflammatory benefits. Proxen is also indicated for musculoskeletal pain, soft tissue injuries, dysmenorrhea, and acute postoperative pain. It offers prolonged action compared to some other NSAIDs, requiring less frequent dosing throughout the day. Clinicians often choose it for chronic pain management due to its favorable efficacy profile and its ability to significantly improve the quality of life in patients with inflammatory conditions.

MECHANISM OF ACTION

Naproxen Sodium exerts its therapeutic effects by non-selectively inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for the conversion of arachidonic acid into prostaglandins and thromboxanes. Prostaglandins are key mediators of pain, inflammation, and fever. By reducing their synthesis, Naproxen effectively diminishes inflammation at the site of injury, lowers pain perception at both peripheral and central levels, and normalizes elevated body temperature. Its sodium salt formulation allows for faster absorption compared to naproxen base, leading to a more rapid onset of analgesic action.

DOSAGE AND ADMINISTRATION

●     For pain and inflammation in adults: 500mg twice daily, or 250mg three times daily as directed.

●     For acute gout: 750mg initially, followed by 250mg every 8 hours until the attack subsides.

●     For dysmenorrhea: 500mg at onset, then 250mg every 6 to 8 hours as need

●     Maximum daily dose should not exceed 1250mg under any circumstances.

●     Take with food, milk, or antacids to minimize gastrointestinal irritation.

●     Use the lowest effective dose for the shortest duration necessary.

SIDE EFFECTS

●     Heartburn, nausea, dyspepsia, and gastric discomfort.

●     Headache, dizziness, and drowsiness.

●     Constipation, diarrhea, and mild peripheral edema.

NOT RECOMMENDED IN

Proxen 500mg is contraindicated in patients with active peptic ulcer disease, gastrointestinal bleeding, or a history of NSAID-induced hypersensitivity reactions including urticaria, rhinitis, or asthma. It must not be used in patients with severe renal or hepatic impairment, or those with decompensated heart failure. This medication is not recommended in the third trimester of pregnancy as it can affect fetal renal function and cause premature closure of the ductus arteriosus. Patients who have undergone recent coronary artery bypass graft (CABG) surgery should avoid this medication. Long-term users should undergo periodic monitoring of renal function, liver enzymes, and complete blood counts.

DRUG INTERACTIONS

Proxen 500mg interacts significantly with a number of medications, and concurrent use warrants careful consideration. Combining Naproxen with other NSAIDs or aspirin increases the risk of gastrointestinal bleeding and ulceration. Anticoagulants such as warfarin may have their effects potentiated by Naproxen, increasing bleeding risk and requiring INR monitoring. ACE inhibitors and angiotensin receptor blockers may lose antihypertensive efficacy when combined with NSAIDs, and the combination can impair renal function. Diuretics may be rendered less effective, and patients on lithium therapy may experience increased lithium toxicity. Methotrexate toxicity can increase when co-administered with Naproxen due to reduced renal clearance.

STORAGE INSTRUCTIONS

Store Proxen 500mg tablets at room temperature below 25°C. Protect from light, heat, and humidity. Keep the medication in its original sealed packaging. Store away from children and pets. Do not use the product past the expiry date. Unused tablets should be disposed of through authorized medical waste disposal facilities.

WHERE TO BUY

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