Primaquin 7.5mg Tablets Online At Best Price In Pakistan

GENERIC: Primaquine Phosphate 7.5mg

MANUFACTURER: Actiza Pharmaceutical Laboratories

QUANTITY:

Each pack contains 14 tablets

INDICATION

Primaquin 7.5mg is a well-established antimalarial medication primarily prescribed for the radical cure of Plasmodium vivax and Plasmodium ovale malaria. It effectively eliminates dormant liver-stage parasites, known as hypnozoites, which are responsible for relapsing episodes of malaria. Physicians also recommend this medication for the prevention of malaria relapse in patients who have already completed blood-stage treatment. Additionally, Primaquin serves as a gametocytocidal agent, helping to reduce the transmission of malaria by destroying gametocytes in the blood.

MECHANISM OF ACTION

Primaquine operates by interfering with the mitochondrial electron transport chain of the malaria parasite. It is metabolized in the body to produce reactive oxygen species that are toxic to Plasmodium parasites residing in liver cells. These reactive intermediates disrupt the parasite's energy production and membrane integrity, ultimately leading to its destruction. Unlike many antimalarials that target blood-stage parasites, Primaquine uniquely acts on the hepatic (liver) stage, making it irreplaceable in preventing relapse and reducing onward transmission of the disease.

DOSAGE AND ADMINISTRATION

●     Radical cure of P. vivax malaria: 15mg (two tablets of 7.5mg) once daily for 14 days, taken with food.

●     Pediatric dose: 0.25mg/kg body weight per day for 14 days; always consult a physician before use in children.

●     For malaria transmission reduction: a single dose as directed by a healthcare provider.

●     Always take with or after meals to minimize gastrointestinal discomfort.

●     Complete the full prescribed course even if symptoms improve early.

SIDE EFFECTS

●     Nausea, vomiting, stomach cramps, and loss of appetite.

●     Mild abdominal discomfort, especially when taken on an empty stomach.

●     Headache, dizziness, and general weakness.

●     Hemolytic anemia, particularly in patients with G6PD deficiency.

●     Methemoglobinemia presents as cyanosis, shortness of breath, or bluish discoloration of the skin.

●     Leukopenia and agranulocytosis in prolonged use.

NOT RECOMMENDED IN

Primaquin 7.5mg is strictly contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as it can cause life-threatening hemolytic anemia in such individuals. It should not be used during pregnancy because of the risk of hemolytic disease in the fetus. Nursing mothers should avoid this medication unless necessary and under close medical supervision. Patients with a history of bone marrow suppression, lupus erythematosus, or rheumatoid arthritis currently receiving myelosuppressive agents should not use this drug.

DRUG INTERACTIONS

Primaquine can interact with several medications, potentially altering their effectiveness or increasing the risk of adverse effects. Concurrent use with other hemolytic agents such as dapsone, sulfonamides, or nitrofurantoin significantly raises the risk of hemolytic anemia and should be avoided. Mepacrine (quinacrine) inhibits the metabolism of primaquine, leading to elevated plasma concentrations and increased toxicity. Combining primaquine with bone marrow suppressants can potentiate hematological toxicity, necessitating careful monitoring of blood counts. Antacids containing magnesium or aluminum salts may reduce the absorption of primaquine if taken simultaneously.

STORAGE INSTRUCTIONS

Store Primaquin 7.5mg tablets at room temperature, ideally between 15°C and 25°C. Keep the product away from direct sunlight, heat sources, and moisture. Store in the original packaging to protect from light. Keep out of reach of children.

WHERE TO BUY

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