Maclusa Tablets Online At Best Price In Pakistan

GENERIC: Sofosbuvir 400 mg + Velpatasvir 100 mg

MANUFACTURER: Macter International (Pvt.) Ltd.

QUANTITY

28 Tablets

INDICATION

Maclusa Tab is a fixed-dose antiviral combination tablet indicated for the treatment of chronic hepatitis C virus (HCV) infection in adults across all six major genotypes (1–6). It is a highly effective pan-genotypic treatment option that can be used with or without ribavirin, depending on the patient's clinical profile and liver condition. Maclusa is suitable for treatment-naive and treatment-experienced patients, including those with compensated cirrhosis. The combination of sofosbuvir and velpatasvir provides broad-spectrum viral suppression by targeting two essential components of HCV replication. Clinical trials have demonstrated sustained virological response (SVR) rates exceeding 95% with a standard 12-week treatment course. Maclusa offers a simplified, once-daily regimen that significantly improves treatment adherence.

MECHANISM OF ACTION

Sofosbuvir acts as a nucleotide analogue inhibitor targeting the HCV NS5B RNA-dependent RNA polymerase, a key enzyme required for viral RNA replication. Once converted inside the cell to its active triphosphate form, it gets incorporated into the viral RNA chain, leading to premature termination of replication. Velpatasvir, on the other hand, is a potent pan-genotypic NS5A inhibitor that interferes with both viral replication and assembly by inhibiting the function of the NS5A protein within the replication complex. This combination of mechanisms helps reduce the likelihood of viral resistance.

DOSAGE AND ADMINISTRATION

•      One tablet once daily for 12 weeks (with or without food).

•      For decompensated cirrhosis: combine with ribavirin for 12 weeks.

•      Swallow whole; do not crush or split the tablet.

•      No dose adjustment required for mild to moderate renal or hepatic impairment.

•      The duration of treatment should be determined by a hepatologist based on the patient’s clinical condition.

SIDE EFFECTS

•      Headache

•      Fatigue and asthenia

•      Nausea

•      Insomnia

•      Rash

•      Rare: bradycardia (when combined with amiodarone), serious symptomatic bradycardia

NOT RECOMMENDED IN

Maclusa is contraindicated in patients taking amiodarone due to the risk of serious symptomatic bradycardia. Co-administration with potent P-gp inducers such as rifampicin, carbamazepine, or St. John's Wort is contraindicated as they significantly reduce sofosbuvir and velpatasvir plasma concentrations. Not recommended in patients with severe renal impairment (eGFR <30 mL/min). Use during pregnancy requires careful evaluation; ribavirin co-administration is absolutely contraindicated in pregnancy.

DRUG INTERACTIONS

Maclusa is subject to important drug interactions primarily through P-glycoprotein and CYP450 enzyme pathways. Proton pump inhibitors may reduce velpatasvir absorption; if needed, omeprazole 20mg can be taken simultaneously with food. Antacids should be separated by at least 4 hours. Statins metabolized by OATP1B1/3 may have increased exposure when co-administered with Maclusa, requiring careful dose monitoring. Anticonvulsants and antiretroviral regimens containing tenofovir should be used with caution.

STORAGE INSTRUCTIONS

Store below 30°C in original blister packaging. Keep away from light and moisture. Do not refrigerate. Keep out of reach of children. Do not use beyond the printed expiry date.

WHERE TO BUY

You can purchase Maclusa tablets online in Pakistan from Dawa Healthcare Pharmacy, a reliable source for hepatitis C treatment medicines. If you want to check the Maclusa tablets price in Pakistan, Dawa Healthcare provides updated pricing along with complete product details on their website. By ordering Maclusa tablets online, you can benefit from same-day delivery through their efficient distribution system. Dawa Healthcare Pharmacy ensures a secure, convenient, and dependable way to obtain antiviral medications across Pakistan. Visit their website to begin your hepatitis C treatment journey with confidence.