LOTON 0.5% /5ML DROP ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Loteprednol Etabonate 5mg/ml (0.5%) Ophthalmic Suspension

MANUFACTURER: Medicaids

QUANTITY

5 ml eye drops

INDICATION

Loton 0.5% Eye Drop is a topical ophthalmic corticosteroid indicated for the treatment of steroid-responsive inflammatory conditions of the anterior segment of the eye, including post-operative inflammation and pain following ocular surgery, seasonal allergic conjunctivitis, anterior uveitis, and other inflammatory conditions where corticosteroid therapy is appropriate. Loteprednol etabonate is specifically designed to provide effective anti-inflammatory action with a reduced risk of intraocular pressure elevation compared to conventional ophthalmic steroids.

MECHANISM OF ACTION

Loteprednol etabonate is a C-20 ester corticosteroid designed using retrometabolic drug design principles. It exerts potent anti-inflammatory activity by binding to glucocorticoid receptors, inducing lipocortin synthesis, and inhibiting phospholipase A2. This blocks arachidonic acid release and suppresses the production of prostaglandins, leukotrienes, and other inflammatory mediators in ocular tissues. The unique advantage of loteprednol is its structural design: after exerting its therapeutic effect, it is rapidly metabolized by ocular esterases into inactive metabolites. This predictable deactivation significantly lowers the risk of steroid-induced IOP elevation and cataract formation compared to prednisolone or dexamethasone, making it one of the safest ophthalmic corticosteroids for conditions requiring prolonged treatment.

DOSAGE AND ADMINISTRATION

●     Instill 1 to 2 drops into the conjunctival sac of the affected eye 4 times daily

●     For post-operative inflammation: begin treatment 24 hours after surgery and continue for 2 weeks

●     For allergic conjunctivitis: use during the symptomatic period as directed by a physician

●     Shake well before each use as this is a suspension formulation

●     Taper gradually when discontinuing after prolonged use to prevent rebound inflammation

●     Do not touch the dropper tip to the eye or any surface

●     Remove contact lenses before instillation and wait at least 10 minutes before reinserting

SIDE EFFECTS

Common:

●     Transient burning or stinging on instillation

●     Temporary blurring of vision after application

●     Mild eye discomfort or foreign body sensation

Less common:

●     Elevated intraocular pressure, though significantly less frequent than with prednisolone or dexamethasone

●     Headache

●     Rhinitis or pharyngitis

●     Secondary ocular infection due to immunosuppressive effect with prolonged use

●     Posterior subcapsular cataract with very prolonged therapy

NOT RECOMMENDED IN

●     Viral diseases of the cornea and conjunctiva including herpes simplex keratitis, vaccinia, and varicella

●     Fungal or mycobacterial ocular infections

●     Acute, untreated purulent bacterial eye infections

●     Known hypersensitivity to loteprednol etabonate or any component of the formulation

DRUG INTERACTIONS

If used alongside other ophthalmic preparations, maintain at least a 5-minute interval between applications to prevent washout and dilution. Anti-glaucoma medications may require dose adjustment if IOP rises during treatment, though this is less common with loteprednol than with other ophthalmic steroids. No significant systemic drug interactions occur with topical loteprednol due to its rapid local metabolism to inactive metabolites.

STORAGE INSTRUCTIONS

Store between 15 to 25 degrees Celsius. Protect from light. Do not freeze. Shake well before each use. Discard 28 days after first opening. Keep out of reach of children.

WHERE TO BUY

Dawa Healthcare Pharmacy at dawahealthcare.biz is the trusted destination to buy Loton 0.5% 5ML Drop online. The Loton 0.5% 5ML Drop uses and the Loton 0.5% 5ML Drop price in Pakistan are detailed on our listing. Dawa Healthcare maintains multiple branches across Karachi, each upholding strict quality standards for ophthalmic medications. Same-day delivery covers all Karachi areas, and nationwide courier service ensures patients across Pakistan receive the same reliable access. WhatsApp ordering at each branch provides direct pharmacist support.