Levelanz 500mg Tablets Online At Best Price In Pakistan

GENERIC: Levetiracetam 500mg

MANUFACTURER: Abbott Laboratories Pakistan

QUANTITY

10 Tablets

INDICATION

Levelanz 500mg is indicated for adjunctive treatment of partial-onset seizures in adults and adolescents above 16 years of age. It is also used in the management of myoclonic seizures associated with juvenile myoclonic epilepsy and primary generalized tonic-clonic seizures. The higher strength formulation is typically prescribed once a lower dose has been tolerated and further seizure control is required. It provides greater anticonvulsant coverage for patients with moderate to severe epilepsy. Long-term use of Levelanz 500mg has shown sustained reduction in seizure frequency with a well-documented safety profile. It remains a preferred choice for neurologists managing refractory epilepsy cases.

MECHANISM OF ACTION

Levetiracetam at a 500mg concentration works by binding to the synaptic vesicle glycoprotein SV2A, a key regulator of neurotransmitter exocytosis in central nervous system neurons. By modulating this protein, levetiracetam prevents abnormal synchronous neuronal firing that characterizes epileptic seizures. Additionally, it reduces intracellular calcium mobilization and counteracts certain inhibitory mechanisms, thereby restoring the normal balance between neuronal excitation and inhibition in the brain.

DOSAGE AND ADMINISTRATION

•      Adults: 500mg twice daily; may be increased up to 1500mg twice daily as clinically required.

•      Dose adjustments should be guided by the neurologist's assessment.

•      Swallow tablets whole with a full glass of water, with or without meals.

•      Patients with renal impairment must receive a modified dose.

•      Avoid sudden discontinuation; tapering is strongly recommended.

SIDE EFFECTS

•      Somnolence and sedation

•      Irritability and mood disturbances

•      Headache

•      Infection and nasopharyngitis

•      Weakness and asthenia

•      Rare: psychotic symptoms, hepatic dysfunction

NOT RECOMMENDED IN

Levelanz 500mg is contraindicated in patients hypersensitive to levetiracetam. It should be used with significant caution in patients with kidney disease, where dose modification is essential. Patients with a history of psychiatric illness, including suicidal behavior, require close monitoring. Not recommended during the first trimester of pregnancy unless clearly necessary.

DRUG INTERACTIONS

Levelanz 500mg displays low potential for drug-drug interactions owing to its limited hepatic metabolism. When taken alongside other antiepileptic drugs such as carbamazepine, the plasma concentration of levetiracetam may be slightly reduced due to enzyme induction. Concurrent use with CNS depressants, including benzodiazepines or opioids, can amplify sedative effects.

STORAGE INSTRUCTIONS

Store below 25°C in a dry location away from direct sunlight and humidity. Keep in original packaging until use. Store away from children and pets. Discard any unused tablets after the expiry date.

WHERE TO BUY

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