ACURON INJECTION 3ML ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Atracurium Besylate 25mg/2.5ml (10mg/ml)

MANUFACTURER: Brookes Pharma (Pvt) Ltd

QUANTITY:

5×3ml ampoule

INDICATION

Acuron Inj is a non-depolarizing neuromuscular blocking agent indicated as an adjunct to general anaesthesia to produce skeletal muscle relaxation during surgery, to facilitate endotracheal intubation, and to provide controlled muscle relaxation during mechanical ventilation in intensive care unit patients. It is used when muscle relaxation is required during surgical procedures and in mechanically ventilated patients who require sedation and paralysis.

MECHANISM OF ACTION

Atracurium besylate is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at nicotinic receptors on the motor end plate of skeletal muscle, blocking neuromuscular transmission and causing skeletal muscle paralysis. It does not affect consciousness, pain perception, or autonomic function at clinical doses. Atracurium undergoes spontaneous chemical degradation (Hofmann elimination) at physiological pH and temperature, making its duration of action largely independent of hepatic and renal function, which makes it suitable for use in patients with organ impairment.

DOSAGE AND ADMINISTRATION

•      Intubation and surgical relaxation: 0.3 to 0.6mg/kg by intravenous bolus

•      Maintenance: 0.1 to 0.2mg/kg boluses or continuous infusion at 5 to 10 micrograms/kg/min

•      ICU sedation and paralysis: continuous infusion titrated to clinical effect and neuromuscular monitoring

•      Administered only by anesthetists or intensivists with full resuscitation facilities available; doses individualized based on patient response

SIDE EFFECTS

Common:

•      Transient hypotension and tachycardia (histamine release)

•      Skin flushing and erythema (histamine release)

•      Bradycardia (less common)

•      Bronchospasm in sensitive patients (histamine-mediated)

Less common:

•      Anaphylaxis and anaphylactoid reactions (rare but potentially fatal; have resuscitation equipment available)

•      Prolonged neuromuscular blockade in critically ill patients

•      Elevated intraocular pressure if used without priming

NOT RECOMMENDED IN

•      Known hypersensitivity to atracurium or other benzylisoquinolinium compounds

•      Patients with myasthenia gravis (extreme sensitivity to neuromuscular blocking agents)

•      Use only by personnel trained in general anaesthesia with ventilatory support immediately available

•      Adequate anaesthesia and analgesia must be maintained; atracurium provides no sedation or analgesia

DRUG INTERACTIONS

Volatile inhalational anaesthetic (halothane, isoflurane) potentiates neuromuscular blockade; reduce atracurium dose accordingly. Aminoglycosides, lincomycin, clindamycin, and polymyxins enhance and prolong blockade. Calcium channel blockers and lithium may potentiate neuromuscular blockade. Anticholinesterases (neostigmine, pyridostigmine) reverse the block and are used as antidotes at end of surgery. Corticosteroids and phenytoin may cause resistance to blockade with long-term use.

STORAGE INSTRUCTIONS

Store between 2°C and 8°C (refrigerate). Protect from light. Do not freeze. Keep out of reach of children.

WHERE TO BUY

You can buy Acuron Injection 3ml online from Dawa Healthcare Pharmacy at dawahealthcare.biz, one of Pakistan's most trusted pharmacies for authentic, pharmacist-verified medicines. Browse our product page to check the current Acuron Injection 3ml price in pakistan, read detailed clinical information, and place your order from the comfort of your home. Our experienced pharmacy team is always available to answer your questions about Acuron Injection 3ml uses and correct dosage. Customers in Karachi enjoy same-day delivery on orders placed before the daily cutoff, while customers across Pakistan benefit from our nationwide courier service for safe and timely delivery to any city. You can also visit any of our Karachi branches in person or reach our dedicated WhatsApp support team for instant help with Acuron Injection 3ml uses, pricing, prescriptions, and order placement.