Tramapar Tablets 20S Online At Best Price In Pakistan

Generic: Tramadol HCl 37.5mg + Paracetamol 325mg

Manufacturer: Efroze Chemical Industries

Quantity:

20 Tablets per pack

INDICATION

Tramapar Tab is a dual-action analgesic combination prescribed for the management of moderate to severe pain that is not adequately controlled by non-opioid analgesics alone. It is indicated for acute pain following surgery or dental procedures, chronic musculoskeletal pain, lower back pain, pain associated with osteoarthritis, migraine, and other pain conditions requiring both central and peripheral analgesic activity. By combining an opioid-type analgesic with a widely used non-opioid pain reliever, Tramapar delivers superior pain relief through two complementary mechanisms, reducing the overall dose of each component needed for effective analgesia.

MECHANISM OF ACTION

Tramapar combines two analgesics with different but complementary pain-relieving mechanisms. Tramadol acts centrally in the brain and spinal cord by binding weakly to mu-opioid receptors and simultaneously inhibiting the reuptake of serotonin and norepinephrine, enhancing the body's natural pain suppression pathways. Paracetamol acts peripherally and centrally by inhibiting prostaglandin synthesis in the central nervous system and blocking pain signal transmission at the spinal level, while also reducing fever. Together, they produce a synergistic analgesic effect that targets pain through two independent pathways, making the combination more effective than either drug alone at lower individual doses.

DOSAGE AND ADMINISTRATION

•      Adults: One tablet every four to six hours as needed for pain relief.

•      Maximum dose: Four tablets per day (equivalent to 1300mg paracetamol and 150mg tramadol).

•      Use for the shortest duration possible; do not exceed the prescribed dose or duration to reduce dependency risk.

SIDE EFFECTS

•      Common: Nausea, vomiting, dizziness, drowsiness, constipation, dry mouth.

•      Less common: Sweating, headache, seizures (rare), respiratory depression (rare at standard doses), liver toxicity (with overdose of paracetamol).

NOT RECOMMENDED IN

Tramapar Tab is contraindicated in patients with known hypersensitivity to tramadol, paracetamol, or other opioids. It must not be used concurrently with MAOIs or within 14 days of MAOI discontinuation. Not recommended for patients with severe hepatic impairment due to paracetamol hepatotoxicity risk, or in those with severe renal impairment. Not suitable for children under 16 years of age. Patients with a history of epilepsy or seizures should use this medication with extreme caution.

DRUG INTERACTIONS

Co-administration with MAOIs is strictly contraindicated, as it can cause serotonin syndrome. Concurrent use with CNS depressants including benzodiazepines, antidepressants, antipsychotics, sedatives, and alcohol significantly increases the risk of sedation and respiratory depression. Tramadol with SSRIs or SNRIs further raises the risk of serotonin syndrome. Warfarin and other anticoagulants may have enhanced effects when combined with paracetamol; INR monitoring is advised. CYP3A4 inducers like rifampicin can reduce tramadol efficacy, while inhibitors can increase its plasma levels.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 30°C. Protect from moisture, heat, and direct sunlight. Keep in original packaging. Store out of reach of children. Do not use after the expiry date on the carton.

WHERE TO BUY

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