Slofin 250mg Tablets Newpack Online At Best Price In Pakistan

Generic: Sodium Fusidate 250mg

Manufacturer: Horizon Pharmaceuticals

Quantity:

10 Tablets

INDICATION

Slofin 250mg Tab 10s is the updated pack of sodium fusidate, a targeted antibiotic used for staphylococcal bacterial infections. It is prescribed for skin and soft tissue infections, including impetigo, folliculitis, infected dermatitis, furuncles, infected cuts and abrasions, and wound infections caused by Staphylococcus aureus. It is also indicated for osteomyelitis and septic arthritis where staphylococci are the causative organisms, and as combination therapy in serious MRSA infections.

MECHANISM OF ACTION

Fusidic acid, the active form of sodium fusidate, acts as a protein synthesis inhibitor. It targets the bacterial elongation factor G (EF-G), a protein essential for ribosomal translocation during the translation process. When fusidic acid binds to EF-G after GTP hydrolysis, it locks the factor in an inactive conformation, preventing the ribosome from advancing along the mRNA template. This blockade halts protein synthesis, starving the bacteria of the structural and functional proteins they require to survive and replicate. This targeted mechanism makes it highly effective against staphylococci, which are frequent causes of skin and bone infections.

DOSAGE AND ADMINISTRATION

•      Adults: 500mg (two 250mg tablets) three times daily for most staphylococcal infections.

•      Take with or after meals to reduce nausea and gastrointestinal discomfort.

•      Swallow tablets whole with a glass of water; do not break or chew.

•      Complete the full 10-tablet or physician-prescribed course without stopping early.

•      For combination therapy in MRSA or bone infections, follow the physician's specific dosing plan.

SIDE EFFECTS

•      Common: Nausea, vomiting, stomach cramps, diarrhea, skin rash.

•      Less common: Reversible liver enzyme elevation, jaundice, hepatotoxicity with prolonged high-dose use.

NOT RECOMMENDED IN

Slofin 250mg Tab 10s is not recommended in patients with a known allergy to fusidic acid or sodium fusidate. It requires caution in patients with existing liver problems due to the drug's hepatic metabolism and potential for liver enzyme elevations. Not suitable for infections caused by organisms not sensitive to fusidic acid. Use in pregnancy should be guided by a physician's risk-benefit assessment. Avoid monotherapy in serious or systemic MRSA infections; always combine with another active antibiotic as directed.

DRUG INTERACTIONS

The interaction between sodium fusidate and warfarin is clinically significant; fusidic acid enhances warfarin's anticoagulant effect, and INR should be closely monitored throughout treatment. The combination of sodium fusidate with HMG-CoA reductase inhibitors, particularly atorvastatin, simvastatin, and rosuvastatin, can cause serious muscle toxicity, including rhabdomyolysis; co-administration should be avoided. Fusidic acid may interfere with drugs that are highly protein-bound in plasma. Physicians must be informed of all current medications before prescribing Slofin.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 25°C. Protect from moisture and direct light. Keep in original sealed packaging. Store out of reach of children. Do not use beyond the expiry date on the carton.

WHERE TO BUY

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