Sitaphage 50/500mg Tablets Online At Best Price In Pakistan

Generic: Sitagliptin 50mg + Metformin HCl 500mg

Manufacturer: Martin Dow Pharmaceuticals (Pvt.) Ltd.

Quantity:

14 Tablets

INDICATION

Sitaphage 50mg/500mg Tab is a dual-action antidiabetic combination prescribed for adults with type 2 diabetes mellitus whose blood sugar is not adequately managed by diet and exercise alone or by single-agent therapy. It combines sitagliptin, a DPP-4 inhibitor, with metformin, a biguanide, to deliver complementary glycemic control through two separate and well-established mechanisms. Sitaphage helps lower HbA1c, reduces fasting and after-meal blood glucose, and minimizes the risk of diabetic complications.

MECHANISM OF ACTION

Sitagliptin works by blocking DPP-4, an enzyme that rapidly inactivates GLP-1 and GIP hormones after meals. By protecting these incretins, sitagliptin promotes insulin release from the pancreas in a blood sugar-dependent way and suppresses glucagon, preventing the liver from adding unnecessary glucose to the blood. Metformin reduces hepatic glucose production, increases muscle and tissue uptake of glucose, and modestly lowers intestinal absorption of sugar. Neither agent causes hypoglycemia on their own when used in appropriate patients. Together, they create a well-balanced approach to controlling both fasting and postprandial blood sugar throughout the day.

DOSAGE AND ADMINISTRATION

•      Usual dose: One tablet (50mg/500mg) twice daily with meals to reduce gastrointestinal discomfort.

•      Swallow whole with water; do not break, crush, or chew.

•      Dose adjustments are made by the physician based on glycemic response and kidney function.

•      Take at consistent times each day to maintain stable drug levels and blood sugar control.

•      Never double up if a dose is missed; take the next dose with the following meal.

SIDE EFFECTS

•      Common: Nausea, diarrhea, stomach discomfort, headache, metallic taste in the mouth.

•      Less common: Pancreatitis (rare), nasopharyngitis, upper respiratory infection, hypoglycemia when used with insulin or sulfonylureas.

NOT RECOMMENDED IN

Sitaphage 50mg/500mg Tab is contraindicated in patients with severe renal impairment, metabolic acidosis, or type 1 diabetes. It must be paused before iodinated contrast procedures and for any acute serious illness or surgical procedure. Not suitable for patients with hepatic impairment or known hypersensitivity to either sitagliptin or metformin. Safety in pregnancy is not clearly established; always consult the physician before use.

DRUG INTERACTIONS

Iodinated contrast agents can precipitate acute renal failure and cause dangerous metformin accumulation leading to lactic acidosis; temporarily discontinue metformin before such procedures. Sitagliptin with insulin or sulfonylureas increases the risk of hypoglycemia; dose reduction of those agents may be needed. Cationic drugs, including trimethoprim, may reduce metformin clearance and raise plasma levels. Carbonic anhydrase inhibitors may worsen the risk of metabolic acidosis. All medications, including supplements, must be reviewed before beginning treatment.

STORAGE INSTRUCTIONS

Store at room temperature between 20°C and 25°C. Protect from direct light, moisture, and heat. Keep in original packaging. Store out of reach of children and pets. Do not use after the expiry date on the pack.

WHERE TO BUY

Dawa Healthcare Pharmacy offers a straightforward and reliable way to buy Sitaphage 50mg/500mg Tab 14s online in Pakistan, giving patients easy access to this essential diabetes combination therapy. Those comparing the Sitaphage 50mg/500mg tablets 14s price in Pakistan will find clear and competitive pricing on our website. Order Sitaphage 50mg/500mg Tab online and receive same-day delivery throughout Karachi, while our nationwide courier services bring your medication reliably to every city and town in Pakistan. Our WhatsApp helpline and multiple Karachi branches provide personalized pharmaceutical support for all your diabetes care needs.