SEM-P 2mg/1.5ml Prefilled Pen (Semaglutide)

Quick Answer:  SEM-P 2mg/1.5ml Pen contains Semaglutide, a GLP-1 receptor agonist manufactured locally in Pakistan by Getz Pharma. This prefilled, dial-a-dose pen is the starting strength, used to deliver the 0.25mg and 0.5mg doses during the first 8 weeks of treatment, for type 2 diabetes management alongside diet and exercise. It's a once-weekly subcutaneous injection costing around Rs. 7,600 per pen at Dawa Healthcare, and it's currently in stock, though pricing and stock may change.

·         Active Ingredient: Semaglutide 2mg per 1.5ml pen - a GLP-1 receptor agonist

·         Main Uses: glycemic control in adults with type 2 diabetes (with diet & exercise); cardiovascular risk reduction in adults with type 2 diabetes and established heart disease

·         Dose Role: Starting pack - supplies the 0.25mg and 0.5mg doses used during the first 8 weeks of treatment; not the maintenance strength

·         Frequency: once-weekly subcutaneous injection

·         Access: prescription required; not an over-the-counter medicine

·         Price: ~Rs. 7,600 per pen at Dawa Healthcare (subject to change)

Semaglutide, Sem-P's active ingredient, is a GLP-1 receptor agonist with about 94% similarity to the body's natural GLP-1 hormone. It stimulates insulin release and suppresses glucagon in a glucose-dependent way, while also slowing stomach emptying and reducing appetite. This is why Semaglutide improves blood sugar control in type 2 diabetes and often leads to some weight loss as a secondary effect. Always follow the dose and schedule set by your doctor.

SEM-P 2mg/1.5ml Pen is used for:

·         Glycemic Control: improving blood sugar (glycemic) control in adults with type 2 diabetes, as an adjunct to diet and exercise

·         Cardiovascular Risk Reduction: reducing the risk of major cardiovascular events (such as heart attack or stroke) in adults with type 2 diabetes and established cardiovascular disease

·         Other Uses: use as monotherapy when metformin is unsuitable due to intolerance or contraindication, or in combination with other diabetes medicines such as metformin, SGLT2 inhibitors, or insulin

These uses reflect Sem-P's approved prescribing information for Pakistan (Getz Pharma). Sem-P is approved for type 2 diabetes management, not for chronic weight management - any off-label use for weight loss should only be considered under a doctor's supervision. Sem-P is meant for long-term use under medical supervision, with periodic review by your doctor.

Sem-P is generally prescribed for adults with type 2 diabetes who need better blood sugar control alongside diet and exercise, including those who cannot tolerate metformin or need additional glycemic control - or for adults with type 2 diabetes and established cardiovascular disease - and who have been assessed by a doctor as suitable for GLP-1 therapy.

Avoid Sem-P, or use it only under close medical advice, if you or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN 2), or a known allergy to Semaglutide or any product component. Sem-P is not for type 1 diabetes or diabetic ketoacidosis. If pregnant, planning pregnancy, or breastfeeding, discuss the risks and alternatives with your doctor - Sem-P should be stopped at least 2 months before a planned pregnancy. A history of pancreatitis, diabetic retinopathy, gallbladder disease, kidney problems, or heart failure also warrants careful assessment before starting.

Yes - Sem-P is typically an ongoing, long-term treatment for type 2 diabetes management, for as long as your doctor advises and you tolerate it well. Your doctor will periodically review your blood sugar control, kidney function, and side effects to decide whether to continue, adjust, or stop treatment.

·         Insulin or Sulfonylureas: combining these with Sem-P increases the risk of low blood sugar; your doctor may need to lower their dose

·         Oral Medicines: Sem-P slows stomach emptying, which can affect how quickly other oral medicines are absorbed - tell your doctor about all medicines you take

·         Surgery or Anaesthesia: tell your doctor and anaesthetist that you are using Sem-P before any procedure requiring general anaesthesia or deep sedation, due to a risk of pulmonary aspiration

·         Warfarin: Sem-P has been linked to a fall in INR in patients taking warfarin or similar blood thinners - more frequent INR monitoring is advised

·         Existing Conditions: tell your doctor about any history of pancreatitis, gallbladder disease, kidney disease, diabetic eye disease (retinopathy), or heart failure before starting

Before first use, refrigerate Sem-P at 2-8°C in its original carton, away from light, and do not freeze. After first use, keep it below 25°C or refrigerated for up to 6 weeks, then discard. Keep out of children's reach and sight, and dispose of used needles and syringes safely in a sharps container, never household rubbish.

SEM-P 2mg/1.5ml Pen is available through Dawa Healthcare, with delivery limited to Karachi for cold-chain/injectable items. On receipt, check the batch number, expiry date, and tamper-evident seal against the manufacturer's packaging, and contact the pharmacy with any concerns. Current pricing for all Sem-P packs is listed below.

All Sem-P Strengths & Prices

What is SEM-P 2mg/1.5ml Pen used for?

SEM-P 2mg/1.5ml Pen contains Semaglutide and is used, together with diet and exercise, to improve blood sugar control in adults with type 2 diabetes. It is also used to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established heart disease.

Is SEM-P 2mg/1.5ml Pen the starting pack or a later pack?

SEM-P 2mg/1.5ml Pen is the starting strength of Sem-P, not the maintenance dose. It supplies the 0.25mg and 0.5mg doses used during the first 8 weeks of treatment. Your doctor will usually move you up to the 4mg/3ml pack after that.

What is the correct dose of Sem-P (Semaglutide)?

Sem-P is injected once weekly under the skin. Treatment starts at 0.25mg for at least 4 weeks, then increases to 0.5mg for at least 4 more weeks, then to 1mg for at least 4 more weeks if needed, up to a maximum maintenance dose of 2mg once weekly. Dose increases should only be made on your doctor's advice.

What is the difference between the 2mg/1.5ml and 4mg/3ml Sem-P packs?

The 2mg/1.5ml pack is the starting strength, used to deliver the 0.25mg and 0.5mg doses during the first 8 weeks of treatment. The 4mg/3ml pack is the higher strength, used for the 1mg escalation dose and the 2mg maintenance dose from around week 9 onward. Your doctor will tell you when to switch from the 2mg/1.5ml pack to the 4mg/3ml pack.

Is a prescription required to buy SEM-P 2mg/1.5ml Pen?

Yes, Sem-P is a prescription-only medicine. A valid prescription must be uploaded to order it.

What are the side effects of Sem-P?

The most common side effects are nausea, diarrhoea, decreased appetite, and low blood sugar when combined with insulin or sulfonylureas. Less common effects include vomiting, abdominal pain, constipation, gallstones, fatigue, and injection site reactions. Serious but rare risks include pancreatitis and severe allergic reactions.

Who should avoid Sem-P?

Avoid it, or seek medical advice first, if you or a family member has a history of medullary thyroid carcinoma or MEN 2, if you have type 1 diabetes, or if you are pregnant or breastfeeding.

How is the Sem-P 2mg/1.5ml Pen injected?

Sem-P pens are injected subcutaneously into the abdomen, thigh, or upper arm once a week. Dial the pen to your prescribed dose (0.25mg or 0.5mg), insert the needle at a 90-degree angle, press the dose button, and hold for 5 seconds before withdrawing.

What happens if I miss a dose of Sem-P?

If you miss a dose, take it within 5 days of the missed dose. If more than 5 days have passed, skip the missed dose and take your next dose on the regular scheduled day.

How should Sem-P be stored?

Before first use, store refrigerated at 2-8°C. After first use, the vial or pen can be kept for up to 6 weeks below 25°C or refrigerated. Do not freeze.

What is the price of SEM-P 2mg/1.5ml Pen in Pakistan?

At Dawa Healthcare, the SEM-P 2mg/1.5ml Pen costs around Rs. 7,600 per pen, though prices and stock availability can change without notice.

How is Sem-P different from Ozempic or Wegovy?

Sem-P contains the same active ingredient, Semaglutide, as Ozempic and Wegovy, but it is manufactured locally in Pakistan by Getz Pharma rather than imported. Like Ozempic, Sem-P is approved for type 2 diabetes management, not for chronic weight management, which is what Wegovy is specifically licensed for.