Methalin Tablets Online At Best Price In Pakistan

GENERIC: L-Methylfolate + Methylcobalamin (Vitamin B12)

MANUFACTURER: Sois Pharma

QUANTITY

30 tablets per pack

INDICATION

Methalin Tablet is a specialized nutritional supplement combining L-methylfolate and methylcobalamin, the active forms of folate and vitamin B12. It is indicated in patients with folate and B12 deficiency, particularly those with impaired folate metabolism, such as MTHFR gene mutations. It serves as an adjunct in depression management, supporting neurotransmitter synthesis (serotonin, dopamine, norepinephrine). Methalin helps reduce elevated homocysteine, a cardiovascular risk factor, supports neural tube development during pregnancy, and is useful in peripheral neuropathy and megaloblastic anemia.

MECHANISM OF ACTION

L-methylfolate is the active form of folic acid that crosses the blood-brain barrier and directly participates in the synthesis of tetrahydrobiopterin (BH4), a cofactor essential for the production of monoamine neurotransmitters. Methylcobalamin (active B12) acts as a cofactor in the methylation cycle, facilitating the remethylation of homocysteine to methionine, which is then converted to S-adenosylmethionine (SAMe), the universal methyl donor in the body. Together, these nutrients support neurological function, DNA methylation, and red blood cell production.

DOSAGE AND ADMINISTRATION

•      One tablet once daily or as directed by a physician.

•      Best taken with food to minimize gastrointestinal discomfort.

•      For pregnancy support: begin at least one month before conception and continue through the first trimester.

•      Patients with MTHFR mutations may require physician-guided dosing adjustments.

•      Do not exceed the recommended daily intake without medical supervision.

SIDE EFFECTS

•      Generally very well tolerated

•      Mild nausea when taken on an empty stomach

•      Mild gastrointestinal discomfort

•      Rare: allergic reactions to excipients

•      Skin flushing at high doses in some patients

NOT RECOMMENDED IN

Methalin Tablet is not recommended for patients with known hypersensitivity to folate, cobalamin, or any excipient in the formulation. Patients with Leber's hereditary optic neuropathy should avoid high-dose B12 supplementation. Undiagnosed megaloblastic anemia should be investigated before supplementation to rule out pernicious anemia. Patients with epilepsy should use high-dose folate with caution, as it may reduce the anticonvulsant efficacy of certain medications.

DRUG INTERACTIONS

L-methylfolate may reduce plasma levels of anticonvulsants such as phenytoin and carbamazepine by enhancing their metabolism, potentially decreasing seizure control. Methotrexate and trimethoprim are folate antagonists that can reduce the efficacy of folate supplementation. Proton pump inhibitors and H2-receptor antagonists may reduce B12 absorption from dietary sources; however, methylcobalamin in Methalin bypasses this interaction. Certain diabetes medications, such as metformin, can reduce B12 levels over time, making supplementation particularly relevant.

STORAGE INSTRUCTIONS

Store below 25°C in a cool, dry place. Keep away from moisture and sunlight. Do not refrigerate. Store in original packaging and out of reach of children.

WHERE TO BUY

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