Masdipine Sr 30mg Tablets Online At Best Price In Pakistan

GENERIC: Nifedipine 30mg (Sustained Release)

MANUFACTURER: Mass Pharma

QUANTITY

20 Tablets

INDICATION

Masdipine SR 30mg is a sustained-release calcium channel blocker indicated for the management of hypertension and chronic stable angina pectoris in adults. The controlled-release formulation ensures a gradual and sustained delivery of nifedipine over 24 hours, providing smooth and consistent blood pressure control. It is used to reduce the frequency and severity of angina episodes by decreasing myocardial oxygen demand. Masdipine SR is also effective in patients with vasospastic or Prinzmetal angina. The once-daily formulation improves patient adherence compared to immediate-release alternatives. It is recommended as part of a comprehensive cardiovascular management plan, including lifestyle modifications.

MECHANISM OF ACTION

Nifedipine is a dihydropyridine calcium channel blocker that selectively inhibits the influx of calcium ions through L-type voltage-gated calcium channels in vascular smooth muscle cells and myocytes. This inhibition causes vasodilation of peripheral arterioles and coronary arteries, reducing systemic vascular resistance and blood pressure. In the heart, reduced calcium entry decreases myocardial oxygen demand and improves coronary blood flow. The SR formulation provides a steady plasma concentration, avoiding the rapid peaks and troughs associated with immediate-release nifedipine.

DOSAGE AND ADMINISTRATION

•      Initial dose: 30mg once daily; may be increased to 60mg once daily if required.

•      Swallow the tablet whole; do not crush, chew, or break.

•      May be taken with or without food.

•      Blood pressure and angina response should be reassessed after 1–2 weeks.

•      Do not discontinue abruptly; gradual dose tapering is recommended.

SIDE EFFECTS

•      Peripheral edema (ankles and feet)

•      Flushing and headache

•      Dizziness

•      Palpitations

•      Nausea

NOT RECOMMENDED IN

Masdipine SR is contraindicated in patients with cardiogenic shock, unstable angina, or acute myocardial infarction. It should not be used in patients with hypersensitivity to nifedipine or other dihydropyridines. Use with caution in patients with severe hypotension, heart failure, or hepatic impairment. Nifedipine is not recommended during the first 20 weeks of pregnancy. Patients undergoing dental procedures should inform their dentist of this medication.

DRUG INTERACTIONS

CYP3A4 metabolizes nifedipine, and concurrent use of CYP3A4 inhibitors such as azole antifungals, macrolide antibiotics, or grapefruit juice can significantly increase nifedipine plasma levels, leading to excessive hypotension. Rifampicin and other CYP3A4 inducers can markedly reduce nifedipine efficacy. Co-administration with beta-blockers can increase the risk of heart failure or severe hypotension. Nifedipine can increase digoxin levels when used together; monitor levels accordingly.

STORAGE INSTRUCTIONS

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep in original blister packaging. Do not refrigerate. Keep out of reach of children.

WHERE TO BUY

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