CEFOT 1GM INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Cefoperazone Sodium 500mg + Sulbactam Sodium 500mg

MANUFACTURER: Swiss Pharmaceuticals (Pvt) Ltd

QUANTITY:

Single vial for injection (1g combined)

INDICATION

Cefot 1gm Inj is a combined third-generation cephalosporin and beta-lactamase inhibitor antibiotic indicated for the treatment of moderate to severe bacterial infections caused by susceptible organisms, including intra-abdominal infections, gynecological infections, lower respiratory tract infections including hospital-acquired pneumonia, urinary tract infections, septicemia, and skin and soft tissue infections. The sulbactam component extends the spectrum to include beta-lactamase-producing organisms.

MECHANISM OF ACTION

Cefoperazone is a third-generation cephalosporin antibiotic effective against many gram-negative bacteria, including Pseudomonas aeruginosa. It works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins. Sulbactam is a beta-lactamase inhibitor that protects cefoperazone from bacterial enzymes that cause resistance. Together, they provide broad-spectrum activity against gram-negative, anaerobic, and some gram-positive bacteria, including ESBL-producing organisms.

DOSAGE AND ADMINISTRATION

•      Adults: 2 to 4g per day in two divided doses by IV infusion or IM injection; may be increased to 8g/day in severe infections

•      1g vial contains 500mg cefoperazone + 500mg sulbactam; standard dose is 1 to 2 vials (1 to 2g) every 12 hours

•      Administer by slow IV infusion over 15 to 60 minutes or by deep IM injection

•      Prescribed and administered by trained healthcare professionals; dose adjustment required in hepatic impairment

SIDE EFFECTS

Common:

•      Diarrhoea (most common, including risk of antibiotic-associated diarrhoea)

•      Skin rash and urticaria

•      Elevated liver enzymes and hyperbilirubinemia

•      Eosinophilia

Less common:

•      Hypoprothrombinemia and bleeding

•      Hypersensitivity reactions including anaphylaxis

NOT RECOMMENDED IN

•      Known hypersensitivity to cephalosporins, penicillins, or sulbactam

•      Patients with bleeding disorders or on anticoagulant therapy (additional monitoring required due to hypoprothrombinemia risk)

•      Severe hepatic impairment (dose adjustment and monitoring required)

DRUG INTERACTIONS

Anticoagulants such as warfarin have significantly enhanced effects when combined with cefoperazone due to hypoprothrombinemia; monitor PT/INR and adjust anticoagulant dose. Alcohol causes a disulfiram-like reaction (flushing, nausea, palpitations, hypotension); strictly avoid during treatment and for 5 days after. Vitamin K supplementation may be required during prolonged courses, particularly in malnourished patients.

STORAGE INSTRUCTIONS

Store unconstituted vials below 25°C away from direct light. Use reconstituted solution immediately or within the stability period. Keep out of reach of children.

WHERE TO BUY

Get Cefot 1gm Inj conveniently at dawahealthcare.biz. Check the Cefot 1gm injection price in pakistan and product details including Cefot 1gm injection uses right on the product description. We have multiple Karachi branches, all staffed by pharmacists. Same-day delivery is available within Karachi, and we provide nationwide delivery across Pakistan. Message us on WhatsApp to place an order.