Sefixim 400mg Tablets Online At Best Price In Pakistan

Generic: Cefixime 400mg

Manufacturer: Evolution Pharmaceuticals

Quantity:

5 Tablets per pack

INDICATION

Sefixim 400mg Tab is a third-generation oral cephalosporin antibiotic prescribed for the treatment of bacterial infections in adults and children above 12 years. It effectively treats urinary tract infections, acute otitis media, pharyngitis, tonsillitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, uncomplicated gonorrhea, and typhoid fever. Sefixim acts against a broad range of Gram-positive and Gram-negative bacteria that are susceptible to cefixime. It is particularly valuable when oral antibiotic therapy is preferred over injectables for moderate infections, offering reliable antibacterial coverage and high bioavailability in a convenient once-daily dosing regimen.

MECHANISM OF ACTION

Cefixime works by attaching to specific proteins called penicillin-binding proteins that are found on the surface of bacterial cell walls. These proteins are responsible for building and maintaining the rigid structure of bacterial walls. When cefixime binds to them, it blocks the final step of cell wall construction. Without a complete and intact cell wall, bacteria cannot maintain their shape or survive internal pressure, causing them to burst and die. Cefixime is also highly stable against many beta-lactamase enzymes that bacteria use to resist antibiotics, making it effective against resistant strains.

DOSAGE AND ADMINISTRATION

•      Adults and children over 12 years or weighing more than 45kg: 400mg once daily, or 200mg twice daily.

•      For uncomplicated gonorrhea: 400mg as a single dose.

•      May be taken with or without food; food may reduce the incidence of gastrointestinal upset.

•      Complete the full prescribed course even if symptoms improve early to prevent antibiotic resistance.

SIDE EFFECTS

•      Common: Diarrhea, nausea, abdominal pain, flatulence, headache.

•      Less common: Skin rash, vomiting, elevated liver enzymes, candidiasis, Clostridium difficile-associated diarrhea (rare).

NOT RECOMMENDED IN

Sefixim 400mg Tab is not recommended in patients with a known allergy to cefixime or other cephalosporin antibiotics. Patients with penicillin hypersensitivity should be evaluated carefully before use, as cross-reactivity can occur. It should not be used for viral infections such as influenza or the common cold. Use with caution in patients with severe renal impairment, as dose reduction may be required.

DRUG INTERACTIONS

Probenecid reduces renal excretion of cefixime, leading to higher and more prolonged plasma concentrations. Antacids containing aluminum or magnesium, as well as iron-containing supplements, can reduce cefixime absorption if taken simultaneously; a two-hour gap is advised. Cefixime may reduce the effectiveness of oral contraceptives, and patients should use additional contraceptive methods during and shortly after treatment. Anticoagulants such as warfarin may show enhanced effects when co-administered; INR monitoring is warranted. Aminoglycosides used concurrently may increase the risk of kidney toxicity.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 25°C. Protect from moisture, heat, and light. Keep in original packaging. Store out of reach of children. Do not use after the expiry date on the label.

WHERE TO BUY

Getting your antibiotic treatment started promptly is important, and Dawa Healthcare Pharmacy makes it easy to buy Sefixim 400mg Tab 5s online in Pakistan with fast and genuine service. Patients checking the Sefixim 400mg tablets 5s price in Pakistan will find our pricing transparent and competitive. You can order Sefixim 400mg Tab online and receive same-day delivery within Karachi for orders placed early, while our nationwide courier network ensures delivery to every city and town across Pakistan. Our responsive WhatsApp team and multiple Karachi pharmacy branches are readily available for any inquiries or prescription needs.