{"product_id":"listono-1million-inj","title":"LISTONO 1MILLION INJ","description":"\u003ch1\u003eLISTONO 1 MILLION INJECTION ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eGENERIC: \u003c\/b\u003eColistimethate Sodium (Colistin) 1 million IU\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eMANUFACTURER: \u003c\/b\u003eHorizon Pharmaceuticals\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eSingle vial for injection\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eListono 1 million IU Inj is a polymyxin antibiotic indicated for the treatment of serious and life-threatening infections caused by multidrug-resistant (MDR) gram-negative bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. It is used when other antibiotics have failed or are not suitable, particularly in hospital-acquired pneumonia, bacteremia, urinary tract infections, and sepsis caused by carbapenem-resistant organisms.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eColistimethate sodium is an inactive prodrug that is hydrolyzed in vivo to colistin, the active polymyxin compound. Colistin acts by binding to lipopolysaccharide (LPS) and phospholipids in the outer membrane of gram-negative bacteria, displacing divalent cations and disrupting membrane integrity. This increases membrane permeability, causing leakage of intracellular contents and rapid bactericidal cell death. Because of its unique mechanism targeting the bacterial outer membrane, colistin retains activity against many organisms resistant to all other antibiotic classes.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdults: 2.5 to 5 mg\/kg\/day of colistin base activity in 2 to 4 divided doses by IV infusion\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eLoading dose recommended in critically ill patients: 9 million IU as a single infusion\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDose must be adjusted based on renal function; reduced doses mandatory in renal impairment\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdministered only by intravenous infusion in a hospital or ICU setting under strict medical supervision\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNephrotoxicity: elevated creatinine, reduced urine output (monitor renal function closely)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNeurotoxicity: dizziness, tingling, slurred speech, neuromuscular blockade\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eInjection site reactions with peripheral administration\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNausea and vomiting\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAcute kidney injury requiring dialysis with prolonged high-dose use\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eRespiratory failure due to neuromuscular blockade at high doses\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eBronchospasm with inhaled formulations\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHypersensitivity reactions including rash and anaphylaxis\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eKnown hypersensitivity to colistin or polymyxins\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eMyasthenia gravis (neuromuscular blockade risk)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eConcurrent use with other nephrotoxic agents without close renal monitoring\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNot for intrathecal use unless specifically formulated; hospital use only\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eConcurrent use of aminoglycosides, vancomycin, amphotericin B, or other nephrotoxic agents significantly increases the risk of acute kidney injury; avoid combination or monitor renal function very closely. Neuromuscular blocking agents used with colistin increase the risk of prolonged paralysis and respiratory failure; use with extreme caution in surgical patients. Non-depolarizing muscle relaxants may have enhanced and prolonged effects when combined with colistin. Loop diuretics such as furosemide may potentiate nephrotoxicity.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore constituted vials below 25°C in a dry place away from direct light. Reconstituted solution should be used immediately or within the stability period stated on the label. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Listono 1million Inj online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Listono 1million Inj price in Pakistan and learn about Listono 1million Inj uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Listono 1million Inj uses, pricing, and order placement.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":51629434339611,"sku":"14279","price":801.9,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_872e0b05-4596-4b77-a3e7-63ae6a1cd4b7.jpg?v=1768417516","url":"https:\/\/dawahealthcare.biz\/products\/listono-1million-inj","provider":"Dawa Healthcare","version":"1.0","type":"link"}