{"product_id":"ardcil-4-5g-inj","title":"ARDCIL 4.5G INJ","description":"\u003ch1\u003eARDCIL 4.5G INJECTION ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 14.0pt;\"\u003eGENERIC: \u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; font-weight: normal;\"\u003ePiperacillin 4g + Tazobactam 0.5g (4.5g)\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 14.0pt;\"\u003eMANUFACTURER: \u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; font-weight: normal;\"\u003eBarrett Hodgson Pakistan (Pvt) Ltd\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eQUANTITY: \u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 8.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eSingle-dose vial\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eINDICATION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eArdcil 4.5g Inj is a broad-spectrum combination antibiotic used for the treatment of serious bacterial infections caused by piperacillin-resistant, beta-lactamase-producing organisms. It is indicated for intra-abdominal infections (appendicitis, peritonitis), hospital-acquired pneumonia, skin and soft tissue infections, urinary tract infections (including pyelonephritis), gynaecological infections (including endometritis and pelvic inflammatory disease), bacteraemia associated with the above infections, and febrile neutropenia in immunocompromised patients.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eMECHANISM OF ACTION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eArdcil 4.5g Inj combines piperacillin, an extended-spectrum penicillin antibiotic, with tazobactam, a beta-lactamase inhibitor. Piperacillin exerts bactericidal activity by binding to penicillin-binding proteins (PBPs) on bacterial cell walls, inhibiting the cross-linking of peptidoglycan chains and disrupting cell wall synthesis. This leads to bacterial cell lysis and death. Tazobactam alone has minimal antibacterial activity, but it irreversibly inactivates many beta-lactamase enzymes produced by resistant organisms, thereby protecting piperacillin from enzymatic degradation and restoring its bactericidal activity against resistant strains.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDOSAGE AND ADMINISTRATION\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eAdults: 4.5g intravenous infusion every 6 to 8 hours (3 to 4 times daily)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eSevere infections including nosocomial pneumonia: 4.5g every 6 hours\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eFebrile neutropenia: 4.5g every 6 hours in combination with an aminoglycoside\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eRenal impairment: dose adjustment required based on creatinine clearance\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eEach 4.5g vial should be reconstituted with 20ml of compatible diluent and administered via IV infusion over 30 minutes\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSIDE EFFECTS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 4.0pt 0in 3.0pt 0in;\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eCommon:\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eDiarrhoea, nausea, vomiting\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eRash and skin reactions\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003ePhlebitis or pain at the infusion site\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eHeadache\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 4.0pt 0in 3.0pt 0in;\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eLess common:\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eHypokalaemia (low potassium levels) with prolonged high-dose therapy\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eElevated liver enzymes and hepatotoxicity\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eClostridium difficile-associated diarrhoea (pseudomembranous colitis)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eNeuromuscular excitability or seizures at very high doses\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eLeucopenia or thrombocytopenia with extended courses\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eNOT RECOMMENDED IN\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eKnown hypersensitivity to piperacillin, tazobactam, penicillins, or cephalosporins\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eHistory of severe anaphylactic reaction to any beta-lactam antibiotic\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eUse with extreme caution in patients with severe renal impairment\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003ePhysically incompatible with aminoglycosides — do not mix in the same infusion bag or syringe\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDRUG INTERACTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003ePiperacillin\/tazobactam can reduce the renal tubular secretion of methotrexate, leading to prolonged and elevated methotrexate plasma concentrations with risk of toxicity. Probenecid inhibits the renal excretion of piperacillin and tazobactam, increasing and prolonging their plasma concentrations. Combined use with nephrotoxic agents such as vancomycin may increase the risk of acute kidney injury, particularly in critically ill patients. Concurrent use with anticoagulants such as heparin or warfarin may require more frequent monitoring as piperacillin may affect platelet aggregation at high doses. Piperacillin\/tazobactam is physically incompatible with aminoglycosides such as gentamicin and tobramycin; administer separately.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSTORAGE INSTRUCTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eStore Ardcil 4.5g Inj vials at room temperature below 25°C. Protect from light. After reconstitution, the solution is stable for 12 hours at room temperature or 48 hours when refrigerated at 2°C to 8°C. Discard any unused portion. Keep out of reach of children.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eWHERE TO BUY\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eBuy Ardcil 4.5g Inj online from Dawa Healthcare Pharmacy, a trusted source for hospital-grade antibiotics in Pakistan. Check the Ardcil 4.5g Inj price in Pakistan and get full information on Ardcil 4.5g Inj uses through our expert pharmacy team. Same-day delivery is available in Karachi. Please note that injectable medications are available for Karachi delivery only. Dawa Healthcare Pharmacy serves hospitals, clinics, and individual patients with a wide range of pharmaceutical injectables through its multiple Karachi branches.\u003c\/span\u003e\u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":51629440860443,"sku":"14748","price":1064.2,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_3f4d4964-fe1e-4bd7-b31c-846b15783b1d.jpg?v=1768417615","url":"https:\/\/dawahealthcare.biz\/products\/ardcil-4-5g-inj","provider":"Dawa Healthcare","version":"1.0","type":"link"}