{"title":"Trelagliptin100mg","description":null,"products":[{"product_id":"trelaget-100mg-tab-4s","title":"TRELAGET 100MG TAB 4S","description":"\u003ch1\u003e\u003cspan style=\"mso-ansi-language: EN-US;\"\u003eTrelaget 100mg Tablets Online At Best Price In Pakistan\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp class=\"MsoNormal\" style=\"line-height: normal;\"\u003e\u003cb\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 16.0pt;\"\u003e \u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eGeneric: \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-GB\"\u003eTrelagliptin Succinate 100mg\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eManufacturer: \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-GB\"\u003eGetz Pharma \u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eQuantity: \u003c\/span\u003e\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\"\u003e4 Tablets\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eTrelaget 100mg Tab is a once-weekly DPP-4 inhibitor prescribed as an adjunct to diet and exercise for the improvement of glycemic control in adults with type 2 diabetes mellitus. It represents a significant advancement in diabetes management, as its unique pharmacokinetics allow sustained DPP-4 inhibition for seven days with a single oral dose. This reduces the daily pill burden from 30 tablets per month to just 4, dramatically improving patient adherence. It is suitable as monotherapy when metformin is not tolerated, and as add-on therapy with other antidiabetic agents when blood sugar remains inadequately controlled, offering effective HbA1c reduction with a low risk of hypoglycemia.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eTrelagliptin inhibits the DPP-4 enzyme with exceptional potency and a prolonged binding duration of approximately 30 minutes, compared to seconds for daily DPP-4 inhibitors. This slow dissociation rate means that even one week after a single dose, DPP-4 inhibition remains around 77%. By blocking DPP-4, trelagliptin prevents the breakdown of incretin hormones GLP-1 and GIP. These incretins signal the pancreas to produce more insulin after meals and reduce glucagon from the liver, both in a glucose-dependent manner that prevents dangerous hypoglycemia. This dual hormonal effect lowers fasting and postprandial blood glucose effectively throughout the week.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eRecommended dose: 100mg orally once weekly, on the same day each week.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eMay be taken with or without food.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eSwallow tablets whole with water; do not crush, break, or chew.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eIf a dose is missed, take it as soon as remembered but never take two doses in the same week.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eFor patients with moderate renal impairment (eGFR 30-59), reduce dose to 50mg once weekly; for severe impairment, 25mg once weekly.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eCommon: Nasopharyngitis, upper respiratory tract infection, headache, mild stomach upset.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eLess common: Skin rash, pruritus, elevated liver enzymes, atrial fibrillation (rare), pancreatitis (rare).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eTrelaget 100mg Tab is not recommended for type 1 diabetes or diabetic ketoacidosis. Patients with severe renal impairment require a dose reduction. It should be used with caution in patients with a history of pancreatitis. Patients with known hypersensitivity to trelagliptin or other DPP-4 inhibitors should avoid this medication. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eTrelagliptin has a low potential for drug interactions due to its minimal hepatic metabolism and predominantly renal excretion. When combined with insulin or sulfonylureas, the risk of hypoglycemia increases, ,and dose reductions of those agents may be necessary. Drugs that impair renal function may alter trelagliptin clearance and require monitoring. No clinically significant interactions with metformin, pioglitazone, or statins have been reported. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eStore at room temperature below 30°C. Protect from sunlight and moisture. Keep in original sealed packaging. Store out of reach of children. Do not use after the expiry date on the carton.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eDawa Healthcare Pharmacy is a dependable source for patients who want to buy Trelaget 100mg Tab 4s online in Pakistan, offering Getz Pharma's innovative once-weekly diabetes tablet with fast and reliable delivery. For those comparing the Trelaget 100mg tablets 4s price in Pakistan, our website provides clear and up-to-date pricing. Order Trelaget 100mg Tab online today and enjoy same-day delivery within Karachi, while our trusted courier services deliver across every city and province of Pakistan. Reach our pharmaceutical team via WhatsApp or visit any of our multiple Karachi branches for medication management guidance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\"\u003e \u003c\/span\u003e\u003c\/p\u003e","brand":"GETZ PHARMA","offers":[{"title":"Pack","offer_id":49828227252507,"sku":"12969","price":972.0,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_26382fa7-73fb-4ca5-af4c-23ec937b8300.jpg?v=1736254586"}],"url":"https:\/\/dawahealthcare.biz\/collections\/trelagliptin100mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}