{"title":"Tacrolimus1mg","description":null,"products":[{"product_id":"tacogen-1mg-capsules","title":"TACOGEN 1MG CAPSULES","description":"\u003ch1\u003eTACOGEN 1MG CAPSULE ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003eGENERIC: \u003c\/b\u003eTacrolimus 1mg\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003eMANUFACTURER: \u003c\/b\u003eALLMED Laboratories\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003ePack of 50 capsules\u003c\/p\u003e\n\u003ch2\u003eINDICATION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eTacogen 1mg Capsules is a calcineurin inhibitor immunosuppressant indicated for the prophylaxis of organ rejection in kidney, liver, and heart transplant recipients. It is used as part of combination immunosuppressive regimens to prevent T-lymphocyte mediated immune rejection of the transplanted organ.\u003c\/p\u003e\n\u003ch2\u003eMECHANISM OF ACTION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eTacrolimus binds to the intracellular immunophilin FKBP-12, forming a complex that inhibits calcineurin, a phosphatase required for the activation of the transcription factor NFAT (nuclear factor of activated T cells). Blocking NFAT prevents the transcription of interleukin-2 and other cytokines essential for T-lymphocyte proliferation and activation, thereby suppressing the immune response against the transplanted organ. Tacrolimus is approximately 100 times more potent than cyclosporine on a weight basis in suppressing T-cell activation.\u003c\/p\u003e\n\u003ch2\u003eDOSAGE AND ADMINISTRATION\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDosage is highly individualized based on organ transplanted, body weight, and through blood levels\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eTypical adult kidney transplant: 0.2 to 0.3mg\/kg\/day in two divided doses\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eTherapeutic drug monitoring (trough blood levels) is mandatory throughout therapy\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAlways prescribed and adjusted by a transplant specialist; never self-adjust the dose\u003c\/p\u003e\n\u003ch2\u003eSIDE EFFECTS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eTremor\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHeadache and insomnia\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHyperglycemia and new-onset diabetes mellitus\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHypertension\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNephrotoxicity (dose-dependent; monitor renal function regularly)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNeurotoxicity: seizures, encephalopathy, and leukoencephalopathy\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eQT prolongation\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eIncreased susceptibility to infections and lymphomas with prolonged use\u003c\/p\u003e\n\u003ch2\u003eNOT RECOMMENDED IN\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eConcurrent use with cyclosporine (additive nephrotoxicity; allow 24-hour washout between agents)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eKnown hypersensitivity to tacrolimus or polyoxyl 60 hydrogenated castor oil (in intravenous formulations)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePregnancy and breastfeeding unless absolutely necessary under specialist supervision\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eGrapefruit and grapefruit juice must be strictly avoided throughout therapy\u003c\/p\u003e\n\u003ch2\u003eDRUG INTERACTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStrong CYP3A4 inhibitors including azole antifungals, macrolides, and protease inhibitors markedly increase tacrolimus blood levels, raising toxicity risk; frequent monitoring and dose reduction required. CYP3A4 inducers such as rifampicin, phenytoin, and St John's Wort dramatically reduce tacrolimus levels, risking acute rejection. NSAIDs combined with tacrolimus increase nephrotoxicity. Potassium-sparing diuretics and ACE inhibitors increase hyperkaliemia risk.\u003c\/p\u003e\n\u003ch2\u003eSTORAGE INSTRUCTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore below 25°C in a dry place away from direct light and moisture. Keep in original packaging. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eWHERE TO BUY\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Tacogen 1mg capsules online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Tacogen 1mg capsules price in pakistan and learn about Tacogen 1mg capsules uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Tacogen 1mg capsules uses, pricing, and order placement.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":50439565869339,"sku":"14317","price":7950.0,"currency_code":"PKR","in_stock":false},{"title":"Strip","offer_id":50439565902107,"sku":"14317","price":1590.0,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_66701dbf-df24-4f89-9624-de3d2e07c88a.jpg?v=1751423304"}],"url":"https:\/\/dawahealthcare.biz\/collections\/tacrolimus1mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}