{"title":"Sitagliptin50mgMetformin1000mgXR","description":null,"products":[{"product_id":"glusimet-xr-50-1000mg-tab","title":"GLUSIMET XR 50\/1000MG TAB","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eSitagliptin 50mg+Metformin 1000mg XR\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eSCILIFE","brand":"SCILIFE","offers":[{"title":"Strip","offer_id":47052804129051,"sku":"11595-4775","price":290.3,"currency_code":"PKR","in_stock":true},{"title":"Pack","offer_id":47164210479387,"sku":"11595-4776","price":580.5,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/products\/GLUSIMET-XR-50-1000MG-TAB_ae18fc01-9034-4d79-9014-2f547979c4ed.jpg?v=1707975337"},{"product_id":"tagipmet-xr-50mg-1000mg-tab","title":"TAGIPMET XR 50MG+1000MG TAB","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eSitagliptin 50mg+Metformin 1000mg XR\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eHIGHNOON PHARMA","brand":"HIGHNOON PHARMA","offers":[{"title":"Strip","offer_id":47132558164251,"sku":"5331-2853","price":233.1,"currency_code":"PKR","in_stock":false},{"title":"Pack","offer_id":47164054208795,"sku":"5331-2854","price":466.2,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/image_2.jpg?v=1701478726"},{"product_id":"inosita-xr-50mg-1000mg-tab","title":"INOSITA XR 50MG+1000MG TAB","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eSitagliptin 50mg+Metformin 1000mg XR\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003ePHARM EVO","brand":"PHARM EVO","offers":[{"title":"Strip","offer_id":47056199254299,"sku":"4204-2233","price":333.0,"currency_code":"PKR","in_stock":true},{"title":"Pack","offer_id":47164023701787,"sku":"4204-2234","price":666.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/products\/INOSITA-XR-50MG_1000MG-TAB_6ee1896d-0fb2-4709-8edb-84a860c4b6b2.jpg?v=1706591576"},{"product_id":"treviamet-xr-50mg-1000mg-tab","title":"TREVIAMET XR 50MG+1000MG TAB","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eSitagliptin 50mg+Metformin 1000mg XR\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eGETZ PHARMA","brand":"GETZ PHARMA","offers":[{"title":"Strip","offer_id":47093615722779,"sku":"3993-2217","price":301.9,"currency_code":"PKR","in_stock":true},{"title":"Pack","offer_id":47164023111963,"sku":"3993-2218","price":603.8,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/products\/TREVIAMET-XR-50MG-1000MG-TAB_5b90e1f5-2f87-414a-8c1d-393af3eee814.jpg?v=1705934100"},{"product_id":"tagipmet-xr-50-1000-mg-tab-20s","title":"TAGIPMET XR 50\/1000 MG TAB 20S","description":"\u003ch1\u003eTAGIPMET XR 50\/1000MG TABLET ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003eGENERIC: \u003c\/b\u003eSitagliptin 50mg + Metformin HCl 1000mg (Extended-Release)\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003eMANUFACTURER: \u003c\/b\u003eHighnoon Laboratories (Pvt) Ltd\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003ePack of 20 tablets\u003c\/p\u003e\n\u003ch2\u003eINDICATION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eTagipmet XR 50\/1000mg Tab is an extended-release fixed-dose combination of sitagliptin 50mg and metformin 1000mg indicated for type 2 diabetes mellitus in adults with moderate renal impairment who need the lower sitagliptin dose or in patients requiring once-daily dosing as part of their overall diabetes management plan.\u003c\/p\u003e\n\u003ch2\u003eMECHANISM OF ACTION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eThe 50mg sitagliptin dose provides DPP-4 inhibition appropriate for patients with moderate renal impairment where the 100mg dose requires reduction, while maintaining meaningful incretin augmentation and glucose-dependent insulin secretion enhancement. Extended-release metformin 1000mg ensures gradual drug delivery with reduced gastrointestinal side effects and convenient once-daily dosing.\u003c\/p\u003e\n\u003ch2\u003eDOSAGE AND ADMINISTRATION\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdults: 1 tablet once daily with the evening meal\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePreferred for patients with moderate renal impairment (CrCl 30 to 50 ml\/min)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSwallow whole; do not crush or break the extended-release tablet\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAlways follow the dosage and renal monitoring schedule prescribed by your doctor\u003c\/p\u003e\n\u003ch2\u003eSIDE EFFECTS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNausea and diarrhoea (reduced with XR formulation)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNasopharyngitis\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHeadache\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eMild abdominal discomfort\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eLactic acidosis (rare; greater risk in renal impairment)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePancreatitis (rare)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eVitamin B12 deficiency\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHypoglycaemia with concurrent insulin or sulfonylurea\u003c\/p\u003e\n\u003ch2\u003eNOT RECOMMENDED IN\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eeGFR below 30 ml\/min\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eType 1 diabetes or diabetic ketoacidosis\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHypersensitivity to either component\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eWithhold 48 hours before iodinated contrast procedures\u003c\/p\u003e\n\u003ch2\u003eDRUG INTERACTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eIodinated contrast: stop metformin before procedure. Alcohol: lactic acidosis risk. Cationic drugs reduce metformin clearance. Insulin and sulfonylureas: hypoglycemia risk. Renal function must be monitored especially as dose is already adjusted for renal impairment.\u003c\/p\u003e\n\u003ch2\u003eSTORAGE INSTRUCTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore below 25°C in a dry place away from heat and humidity. Keep in original packaging. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eWHERE TO BUY\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Tagipmet XR 50\/1000 mg tab TAB 20S online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Tagipmet XR 50\/1000 mg tab price in pakistan and learn about Tagipmet XR 50\/1000 mg tab uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Tagipmet XR 50\/1000 mg tab uses, pricing, and order placement.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e","brand":"HIGHNOON PHARMA","offers":[{"title":"Pack","offer_id":49828200251675,"sku":"12797","price":774.0,"currency_code":"PKR","in_stock":true},{"title":"Strip","offer_id":49828200284443,"sku":"12797-1","price":387.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_5880eea9-6570-4561-9d36-4953dad21c98.jpg?v=1736254039"},{"product_id":"sitaglu-met-xr-50-1000-tab-28s","title":"SITAGLU MET XR 50\/1000 TAB 28S","description":"\u003ch1\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003eSitaglu Met Xr 50\/1000mg 28S Tablets Online At Best Price In Pakistan\u003c\/span\u003e\u003c\/h1\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eGeneric: Sitagliptin 50mg + Metformin HCl 1000mg (Extended Release)\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eManufacturer: Hilton Pharma \u003c\/span\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eQuantity: \u003c\/span\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003e28 Tablets per pack\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003eSitaglu Met XR 50\/1000mg Tab is an extended-release combination antidiabetic tablet prescribed for the management of type 2 diabetes mellitus in adults who require a higher metformin dose for adequate glycemic control. The extended-release formulation ensures a slower, more gradual release of metformin throughout the day, significantly reducing gastrointestinal side effects while maintaining steady plasma levels. It is indicated when blood sugar remains inadequately controlled on lower-dose combination therapy or when patients need a once-daily regimen to improve long-term adherence to diabetes treatment alongside diet and exercise.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003eSitagliptin works by inhibiting the DPP-4 enzyme, which breaks down incretin hormones such as GLP-1. When these incretins are preserved, the pancreas responds by producing more insulin, specifically when blood glucose is elevated, and the liver reduces unnecessary glucose output. This mechanism is glucose-dependent, making hypoglycemia rare. Metformin XR works by reducing hepatic glucose production, improving peripheral insulin sensitivity, and decreasing intestinal absorption of glucose. The extended-release technology allows metformin to be absorbed gradually in the lower gastrointestinal tract, improving tolerability while maintaining effective blood sugar control throughout the day.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003e•      Usual dose: One tablet (50mg\/1000mg) once daily with the evening meal.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003e•      Swallow whole with water; do not crush, break, or chew extended-release tablets.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003e•      Dose adjustments should be made by the physician based on HbA1c monitoring and renal function.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003e•      Take at the same time each evening to ensure consistent drug levels.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003e•      Common: Mild nausea, diarrhea, abdominal discomfort (significantly less than immediate-release metformin), headache.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003e•      Less common: Pancreatitis (rare), upper respiratory infection, hypoglycemia with concurrent insulin or sulfonylureas, lactic acidosis (very rare).\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003eSitaglu Met XR 50\/1000mg Tab is contraindicated in severe renal impairment (eGFR below 30 mL\/min), metabolic acidosis, and type 1 diabetes. It should be withheld before contrast-based imaging procedures and resumed 48 hours after, provided renal function is confirmed as normal. It is not indicated in patients with liver disease or hypersensitivity to sitagliptin or metformin. Patients with a history of pancreatitis should be monitored closely.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003eIodinated contrast agents used in imaging can precipitate acute kidney injury, creating a risk of metformin accumulation and lactic acidosis; always pause metformin before such procedures. Alcohol significantly raises the risk of lactic acidosis. Sitagliptin combined with insulin or sulfonylureas increases the risk of hypoglycemia. Drugs that impair renal tubular secretion, such as cimetidine, can elevate metformin levels. Carbonic anhydrase inhibitors, including topiramate and acetazolamide, may increase the risk of metabolic acidosis. \u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003eStore at room temperature between 15°C and 30°C. Protect from heat and moisture. Keep in original sealed packaging. Keep out of reach of children. Do not use after the expiry date on the carton.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\" style=\"mso-ansi-language: EN-GB;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-ansi-language: EN-GB;\"\u003eDawa Healthcare Pharmacy provides patients with a convenient and trustworthy avenue to buy Sitaglu Met XR 50\/1000 Tab 28s online in Pakistan, ensuring a consistent supply of genuine diabetes medications. Those checking the Sitaglu Met XR 50\/1000 tablets 28s price in Pakistan will find accurate pricing displayed on our website at all times. Order Sitaglu Met XR 50\/1000 Tab online and receive same-day delivery within Karachi, while our reliable courier partnerships cover every city across Pakistan. Our accessible WhatsApp channel and widespread Karachi branches ensure professional pharmaceutical support is always within reach.\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 14.0pt; line-height: 115%;\"\u003e \u003c\/span\u003e\u003c\/p\u003e","brand":"HILTON PHARMA","offers":[{"title":"Pack","offer_id":49828228530459,"sku":"12979","price":1200.6,"currency_code":"PKR","in_stock":true},{"title":"Strip","offer_id":49828228563227,"sku":"12979-1","price":600.3,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_00d4c11b-c494-413f-91e6-dfc727be1096.jpg?v=1736254617"}],"url":"https:\/\/dawahealthcare.biz\/collections\/sitagliptin50mgmetformin1000mgxr.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}