{"title":"Sacubitril24mgValsartan26mg","description":null,"products":[{"product_id":"savesto-50-tab-24-26mg-28s","title":"SAVESTO 50 TAB 24+26MG 28S","description":"\u003ch1\u003e\u003cspan lang=\"EN-GB\"\u003eSavesto 50mg Tablets Online At Best Price In Pakistan\u003c\/span\u003e\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eGeneric: \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-GB\"\u003eSacubitril 24 mg + Valsartan 26 mg\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eManufacturer: \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-GB\"\u003eGetz Pharma\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eQuantity: \u003c\/span\u003e\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\"\u003e28 Tablets\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eSavesto 50mg Tab is a low-dose sacubitril-valsartan combination prescribed for adult patients with symptomatic chronic heart failure with reduced ejection fraction (HFrEF). This starting dose formulation is specifically suited for patients not currently taking an ACE inhibitor or ARB, those previously on low doses of these agents, individuals with severe renal impairment, or patients with moderate hepatic impairment. It helps reduce the risk of cardiovascular death and heart failure hospitalizations while allowing the body to gradually adjust to this dual-action therapy before titrating to higher doses for optimal long-term cardiac protection.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eSavesto 50 delivers its heart-protective effects through the simultaneous inhibition of two different pathways. Sacubitril works by blocking neprilysin, an enzyme that normally degrades beneficial heart hormones called natriuretic peptides. By preserving these hormones, the body naturally reduces blood pressure, encourages fluid excretion through the kidneys, and relieves strain on the heart muscle. Valsartan blocks angiotensin II at its receptor, preventing this hormone from constricting blood vessels and causing the heart to work harder. This dual action provides a more complete cardiovascular benefit than single-agent therapy.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eInitial dose for appropriate patients: 24mg\/26mg taken orally twice daily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eIncrease dose to 49mg\/51mg after 2 to 4 weeks, then target 97mg\/103mg twice daily as tolerated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eWhen switching from an ACE inhibitor, allow at least a 36-hour washout period.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eMaintain consistent twice-daily dosing with doses approximately 12 hours apart.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 3.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eCommon: Hypotension, hyperkalemia, dizziness, impaired renal function, cough.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; margin: 0in 0in 3.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eLess common: Angioedema, headache, nausea, fatigue, orthostatic dizziness.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eSavesto 50 Tab is contraindicated with concurrent ACE inhibitor use; a 36-hour gap is mandatory when switching from ACE inhibitors to prevent angioedema. It must not be used during pregnancy as it can cause serious harm to the developing fetus. Patients with a personal or family history of hereditary angioedema should avoid this medication. It is contraindicated in severe hepatic impairment (Child-Pugh C). Patients with bilateral renal artery stenosis should not use this medication without specialist guidance.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eACE inhibitor co-administration is a strict contraindication. NSAIDs may reduce antihypertensive efficacy and increase the risk of acute kidney injury. Potassium-sparing agents, including certain diuretics and salt substitutes, can cause dangerous hyperkalemia. Sacubitril-related OATP1B1 and OATP1B3 inhibition may increase statin concentrations, raising the risk of muscle damage. Lithium plasma levels may rise during concurrent use with valsartan; close monitoring is recommended. Physicians should conduct a full medication review before initiating Savesto 50.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eStore at room temperature, not exceeding 30°C. Protect from moisture, light, and heat. Keep in original packaging. Store out of reach of children. Do not use after the expiry date stated on the carton.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003ePatients beginning heart failure therapy can now easily buy Savesto 50 Tab 24+26mg 28s online in Pakistan through Dawa Healthcare Pharmacy, a reliable and professionally managed pharmaceutical platform. Anyone looking up the Savesto 50 tablets 24+26mg 28s price in Pakistan will find our pricing competitive and transparent. You can order Savesto 50 Tab online and receive same-day delivery within Karachi, while our courier services deliver to every city across Pakistan without delay. Our team is also available on WhatsApp and at our various Karachi branches for prescription guidance and cardiac care support.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%;\"\u003e \u003c\/span\u003e\u003c\/p\u003e","brand":"GETZ PHARMA","offers":[{"title":"Pack","offer_id":49828276109595,"sku":"13164","price":1291.5,"currency_code":"PKR","in_stock":true},{"title":"Strip","offer_id":49828276142363,"sku":"13164-1","price":322.9,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_938ed9ea-9e32-418d-abcd-ddbb48483bcb.jpg?v=1736255378"},{"product_id":"sacvalz-24-26mg-tab","title":"SACVALZ 24 \/26MG TAB","description":"\u003ch1\u003e\u003cspan style=\"mso-ansi-language: EN-US;\"\u003eBuy Sacvalz 24\/26mg Tablet Online At Best Price In Pakistan\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 12.0pt 0in 12.0pt 0in;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-fareast-font-family: 'Times New Roman';\"\u003eGeneric: Sacubitril + Valsartan\u003cbr\u003eManufacturer: Horizon Pharmaceuticals\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eIndication:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 12.0pt 0in 12.0pt 0in;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003cbr\u003eSacvalz 24\/26mg tablet is indicated for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). It combines sacubitril, a neprilysin inhibitor, with valsartan, an angiotensin II receptor blocker, providing dual action for optimal heart failure management. Sacubitril enhances beneficial natriuretic peptides that promote vasodilation and sodium excretion, while valsartan blocks harmful RAAS-mediated vasoconstriction and fluid retention. This combination reduces cardiovascular mortality and hospitalizations related to heart failure. It improves cardiac efficiency, decreases symptoms such as breathlessness and fatigue, and enhances overall quality of life when used as part of comprehensive heart failure therapy.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eAdministration:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 12.0pt 0in 12.0pt .5in;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003cbr\u003e• Take twice daily at evenly spaced intervals.\u003cbr\u003e• May be taken with or without food.\u003cbr\u003e• Swallow whole with water; do not crush or split.\u003cbr\u003e• Blood pressure, renal function, and potassium levels should be monitored regularly.\u003cbr\u003e• Maintain a 36-hour washout period when switching from ACE inhibitors.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSide Effects:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 12.0pt 0in 12.0pt 0in;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003cbr\u003eCommon: hypotension, dizziness\u003cbr\u003eLess common: hyperkalemia, renal impairment\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eAvailability:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 12.0pt 0in 12.0pt 0in;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003cbr\u003eTo buy Sacvalz 24\/26mg tab online in Pakistan, visit \u003ca href=\"https:\/\/dawahealthcare.biz\"\u003eDawa Healthcare Pharmacy\u003c\/a\u003e for genuine and cardiologist-recommended therapy. The platform provides updated details regarding the Sacvalz 24\/26mg tablet price in Pakistan before checkout for transparency. Customers can confidently order Sacvalz 24\/26mg tab online using secure payment gateways. Same-day delivery within Karachi and reliable nationwide shipping services ensure uninterrupted access to essential heart failure treatment.\u003c\/span\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt; line-height: 115%; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"HORIZON PHARMA","offers":[{"title":"Pack","offer_id":49828298719515,"sku":"13349","price":520.8,"currency_code":"PKR","in_stock":true},{"title":"Strip","offer_id":49828298752283,"sku":"13349-1","price":260.4,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_c2ad5ae8-55e6-427b-aca0-08ff7a6745e8.jpg?v=1736255698"}],"url":"https:\/\/dawahealthcare.biz\/collections\/sacubitril24mgvalsartan26mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}