{"title":"Ribavirin400mg","description":null,"products":[{"product_id":"novia-400mg","title":"NOVIA 400MG","description":"\u003cstrong\u003eGeneric Formula: \u003c\/strong\u003eRibavirin 400mg\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eHILTON PHARMA","brand":"HILTON PHARMA","offers":[{"title":"Pack","offer_id":50117666472219,"sku":"14245","price":356.3,"currency_code":"PKR","in_stock":false},{"title":"Strip","offer_id":50117666504987,"sku":"14245-1","price":118.8,"currency_code":"PKR","in_stock":false},{"title":"Unit","offer_id":50439563346203,"sku":"14245","price":11.9,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/NOVIA400MG.jpg?v=1754320136"},{"product_id":"ribazole-400mg-cap","title":"RIBAZOLE 400MG CAP","description":"\u003ch1\u003eRIBAZOLE 400MG CAPSULE ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eGENERIC: \u003c\/b\u003eRibavirin 400mg\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eMANUFACTURER: \u003c\/b\u003eGetz Pharma (Pvt) Ltd\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e10 capsules per pack\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eRibazole 400mg Cap is an antiviral agent indicated for the treatment of chronic hepatitis C virus (HCV) infection in adults, used in combination with pegylated interferon alfa or direct-acting antiviral agents (DAAs). It is never used as monotherapy for hepatitis C as it has no significant antiviral effect when used alone.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eRibavirin is a synthetic nucleoside analogue that is phosphorylated intracellularly to its active triphosphate form. It inhibits the RNA-dependent RNA polymerase of HCV, impairing viral replication. It also has immunomodulatory properties, shifting the immune response from a Th2 to a Th1 profile, which enhances viral clearance. Additionally, ribavirin depletes intracellular GTP pools by inhibiting inosine monophosphate dehydrogenase (IMPDH), further reducing viral RNA synthesis. Its combination with interferon or DAAs significantly improves sustained virological response (SVR) rates in chronic HCV infection.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdults under 75kg: 400mg in the morning and 600mg in the evening (1000mg\/day)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdults 75kg and above: 600mg twice daily (1200mg\/day)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eTake with food to improve absorption and reduce gastrointestinal side effects\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAlways follow the combination regimen and duration prescribed by your hepatologist; never take ribavirin alone for hepatitis C\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHemolytic anemia (most significant; monitor hemoglobin closely throughout therapy)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eFatigue and weakness\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNausea, anorexia, and weight loss\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHeadache and insomnia\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSevere teratogenicity and embryo lethality (extreme caution; two forms of contraception mandatory for both sexes during and for 6 months after therapy)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eWorsening of cardiac disease due to hemolytic anemia\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eRash, pruritus, and dry skin\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDepression and mood disturbances (potentiated by interferon)\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePregnancy and women of childbearing potential or their male partners not using two reliable contraceptive methods simultaneously\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHaemoglobinopathies such as thalassemia and sickle cell anemia\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSevere renal impairment (eGFR below 50 mL\/min; ribavirin accumulates causing severe hemolysis)\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 6.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eKnown hypersensitivity to ribavirin or any excipient\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eRibavirin inhibits phosphorylation of stavudine and zidovudine, reducing their antiviral efficacy; avoid concurrent use in HIV-HCV coinfected patients on these agents. Didanosine combined with ribavirin increases the risk of severe mitochondrial toxicity including lactic acidosis, pancreatitis, and hepatic decompensation; this combination is contraindicated. Azathioprine combined with ribavirin may cause severe pancytopenia through additive myelosuppression; avoid concurrent use. Antacids containing magnesium and Aluminium reduce ribavirin absorption; take ribavirin 2 hours apart from antacids.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore below 25°C in a dry place away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Handle with care; ribavirin is teratogenic and must not be handled by pregnant women.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Ribazole 400mg cap online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Ribazole 400mg cap price in Pakistan and learn about Ribazole 400mg capsule uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Ribazole 400mg capsule uses, pricing, and order placement.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":50439564558619,"sku":"14451","price":345.6,"currency_code":"PKR","in_stock":false},{"title":"Unit","offer_id":50439564591387,"sku":"14451","price":34.6,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/RIBAZOLE400MGCAP.webp?v=1775596577"}],"url":"https:\/\/dawahealthcare.biz\/collections\/ribavirin400mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}