{"title":"NalbuphineHCL10mgml","description":null,"products":[{"product_id":"buphain-10mg-amp","title":"BUPHAIN 10MG (AMP)","description":"\u003ch1\u003eBUPHAIN 10MG (AMP) ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003eGENERIC: \u003c\/b\u003eNalbuphine Hydrochloride 10mg\/ml\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003eMANUFACTURER:\u003c\/b\u003e Barretts Hodgson Pakistan (Pvt) Ltd\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eBox of 10 ampoules\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eBuphain 10mg Amp is an opioid analgesic indicated for the management of moderate to severe acute pain in clinical settings, including post-operative pain, trauma pain, labor pain, and cancer-related pain. It is also used as a pre-operative analgesic and as a supplement to balanced anaesthesia to provide intraoperative analgesia. As a mixed agonist-antagonist opioid, nalbuphine provides effective analgesia with a lower risk of euphoria and abuse potential compared to pure mu-opioid agonists such as morphine.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eNalbuphine is a mixed opioid receptor agonist-antagonist that acts as a kappa-opioid receptor agonist and a partial antagonist at mu-opioid receptors. Kappa receptor agonism in the spinal cord and brain produces analgesia, sedation, and mild dysphoria, without the intense euphoria characteristic of mu-opioid agonists, which is the basis for its lower abuse potential. The partial mu-opioid antagonism means nalbuphine can precipitate withdrawal in patients physically dependent on pure mu-agonists such as morphine, pethidine, or fentanyl if given concurrently or shortly after. Respiratory depression from kappa agonism exhibits a ceiling effect at higher doses, providing a margin of safety compared to full mu-opioid agonists. Onset of action is rapid with intravenous injection (2 to 3 minutes) and duration of analgesia is 3 to 6 hours.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdults: 10 to 20mg by intravenous, intramuscular, or subcutaneous injection every 3 to 6 hours as needed\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eMaximum single dose: 20mg; maximum daily dose: 160mg\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePre-operative and intraoperative use: 0.3 to 3mg\/kg IV as directed by the anesthetist\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eReduce dose in hepatic impairment and elderly patients; administer by trained healthcare professionals only\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSedation and somnolence (most common; may be used therapeutically for post-operative sedation)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNausea and vomiting\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDizziness and sweating\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDry mouth and headache\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eRespiratory depression (ceiling effect limits severity, but monitor closely with CNS depressants)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDysphoria and psychotomimetic effects such as hallucinations (kappa-opioid mediated)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eOpioid withdrawal precipitation in patients dependent on pure mu-opioid agonists\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHypotension and bradycardia with rapid intravenous injection\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eKnown hypersensitivity to nalbuphine or any excipient\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eConcurrent use with pure mu-opioid agonists in opioid-dependent patients (may precipitate acute withdrawal)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSevere respiratory depression or acute bronchial asthma without resuscitation facilities immediately available\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNot for self-administration; use only under direct medical supervision\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eCNS depressants including benzodiazepines, barbiturates, alcohol, and other opioids have additive sedative and respiratory depressant effects; reduce doses and monitor closely. Pure mu-opioid agonists such as morphine and fentanyl have their analgesic effects partially antagonized by nalbuphine due to its partial mu-antagonism; avoid combination or use with caution under specialist guidance. MAO inhibitors combined with opioids increase the risk of serotonin-like reactions including hyperthermia and CNS excitation; avoid concurrent use or within 14 days of stopping an MAO inhibitor. Nalbuphine does not interact significantly with CYP450 enzymes and has limited pharmacokinetic drug interactions.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore below 25°C in a dry place away from direct sunlight and moisture. Protect from freezing. Keep in original box. This medicine is a controlled opioid substance; store securely to prevent misuse. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Buphain 10mg amp online from Dawa Healthcare Pharmacy at dawahealthcare.biz, one of Pakistan's most trusted pharmacies for authentic, pharmacist-verified medicines. Browse our product page to check the current Buphain 10mg amp price in pakistan, read detailed clinical information, and place your order from the comfort of your home.. Customers in Karachi enjoy same-day delivery on orders placed before the daily cutoff, while customers across Pakistan benefit from our nationwide courier service for safe and timely delivery to any city. You can also visit any of our Karachi branches in person or reach our dedicated WhatsApp support team for instant help with Buphain 10mg amp uses, pricing, prescriptions, and order placement.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e","brand":"MACTER INTERNATIONAL LIMITED","offers":[{"title":"Pack","offer_id":47054937719067,"sku":"1278-871","price":527.5,"currency_code":"PKR","in_stock":false},{"title":"Unit","offer_id":47163965145371,"sku":"1278-872","price":52.8,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/buphan.png?v=1779179592"},{"product_id":"buehain-10mg-inj","title":"BUEHAIN 10MG INJ","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eNalbuphine HCL 10mg\/ml\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eMACTER INTERNATIONAL LIMITED","brand":"MACTER INTERNATIONAL LIMITED","offers":[{"title":"Pack","offer_id":47054937784603,"sku":"10310-4143","price":413.5,"currency_code":"PKR","in_stock":false},{"title":"Unit","offer_id":47164136751387,"sku":"10310-4144","price":41.3,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/products\/BUEHAIN-10MG-INJ.jpg?v=1707016550"},{"product_id":"kinz-10mg-amp","title":"KINZ 10MG (AMP)","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eNalbuphine HCL 10mg\/ml\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eSAMI PHARMA","brand":"SAMI PHARMA","offers":[{"title":"Pack","offer_id":47056370434331,"sku":"1481-997","price":655.5,"currency_code":"PKR","in_stock":true},{"title":"Unit","offer_id":47163968487707,"sku":"1481-998","price":131.1,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/products\/KINZ-10MG--AMP_927700ff-9453-4639-89f6-a4f281fc4356.jpg?v=1706591632"},{"product_id":"buphinal-10mg-inj","title":"BUPHINAL 10MG INJ","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eNalbuphine HCL 10mg\/ml\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eBARRETTS HODGSON PAKISTAN (PVT).LTD","brand":"BARRETTS HODGSON PAKISTAN (PVT).LTD","offers":[{"title":"Pack","offer_id":47093510340891,"sku":"6883-3707","price":602.3,"currency_code":"PKR","in_stock":false},{"title":"Unit","offer_id":47164097069339,"sku":"6883-3708","price":60.2,"currency_code":"PKR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/b9a056b2-db32-412e-bce1-4caee377d418_600x_0597dd9e-3b9c-4b29-b33b-6c7fd316cdd4.jpg?v=1704247101"}],"url":"https:\/\/dawahealthcare.biz\/collections\/nalbuphinehcl10mgml.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}