{"title":"HYDROXYUREAUSP","description":null,"products":[{"product_id":"hydrourea-500mg-capsules","title":"HYDROUREA 500MG CAPSULES","description":"\u003ch1\u003eHYDROUREA 500MG CAPSULE ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 14.0pt;\"\u003eGENERIC: \u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; font-weight: normal;\"\u003eHydroxycarbamide (Hydroxyurea) 500mg\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 14.0pt;\"\u003eMANUFACTURER:\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; font-weight: normal;\"\u003e Pharmedic\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eQUANTITY:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e100 capsules per pack\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eINDICATION\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eHydrourea 500mg Capsules are used in the treatment of sickle cell disease to reduce the frequency of painful crises and the need for blood transfusions. It is also indicated in certain myeloproliferative disorders including chronic myeloid leukemia (CML), polycythemia vera, and essential thrombocythemia.\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eHydroxyurea is an antineoplastic and anti-sickle cell agent that inhibits ribonucleotide reductase, an enzyme required for the conversion of ribonucleotides to deoxyribonucleotides, which are essential for DNA synthesis. This blocks the S phase of the cell cycle and results in cytoreduction. In sickle cell disease, hydroxyurea increases fetal hemoglobin (HbF) production, which dilutes the polymerizing HbS and reduces sickling, vaso-occlusion, and hemolysis.\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSickle cell disease: initial dose 15mg\/kg\/day, titrated to response and toxicity\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eMyeloproliferative disorders: 20 to 30mg\/kg\/day initially\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDose adjustments based on blood counts; requires regular monitoring\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAlways prescribed and managed by a hematologist; do not self-adjust dose\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eBone marrow suppression: anemia, leucopenia, thrombocytopenia\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNausea and vomiting\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eOral mucositis and mouth ulcers\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSkin rash and leg ulcers with long-term use\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePulmonary toxicity\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eElevated creatinine (renal toxicity)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePeripheral neuropathy\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSecondary leukemia with prolonged use (rare)\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePregnancy (teratogenic; avoid during pregnancy and use contraception)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eBreastfeeding women\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSevere bone marrow depression or very low blood counts\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eKnown hypersensitivity to hydroxyurea\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eHydroxyurea used with other myelosuppressive agents, radiation therapy, or antiretroviral drugs such as diagnosing increases the risk of severe bone marrow suppression and neurotoxicity. Concurrent use with stavudine in HIV patients significantly increases pancreatitis and neuropathy risk. Live vaccines should be avoided during therapy. Regular blood count monitoring is essential to detect early toxicity.\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore below 25°C in a dry place away from heat, moisture, and direct sunlight. Keep in original packaging. Keep out of reach of children and handle with care; wash hands after handling.\u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 13.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Hydrourea 500mg capsules online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Hydrourea 500mg capsules price in Pakistan and learn about Hydrourea 500mg capsules uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Hydrourea 500mg capsules uses, pricing, and order placement.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e \u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":51629426966811,"sku":"14039","price":1377.5,"currency_code":"PKR","in_stock":true},{"title":"Strip","offer_id":51629426999579,"sku":"14039-1","price":137.8,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_cd8bf590-ac27-4152-b92c-87647250b945.jpg?v=1768417375"}],"url":"https:\/\/dawahealthcare.biz\/collections\/hydroxyureausp.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}