{"title":"CINACALCETHCI","description":null,"products":[{"product_id":"mimcipar-30mg-tab","title":"MIMCIPAR 30MG TAB","description":"\u003ch1\u003e\u003cspan style=\"mso-ansi-language: EN-US;\"\u003eMimcipar 30mg Tablets Online At Best Price In Pakistan\u003c\/span\u003e\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eGENERIC: \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-GB\"\u003eCinacalcet 30mg\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eMANUFACTURER: \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-GB\"\u003eAllianze Med Pharma\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003e\u003cspan lang=\"EN-GB\"\u003eQUANTITY\u003c\/span\u003e\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan lang=\"EN-GB\"\u003e10 Tablets\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 5.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eMimcipar 30mg is indicated for the treatment of secondary hyperparathyroidism (SHPT) in adult patients with chronic kidney disease on dialysis. It is also used in the management of hypercalcemia associated with parathyroid carcinoma and in patients with primary hyperparathyroidism for whom parathyroidectomy is indicated but clinically inappropriate. Cinacalcet effectively reduces elevated parathyroid hormone (PTH), calcium, and phosphorus levels in dialysis patients, thereby minimizing the risk of cardiovascular complications and renal osteodystrophy. Mimcipar plays a critical role in preserving bone mineral density in patients with mineral metabolism disturbances. It is a first-in-class calcimimetic agent available in Pakistan.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 5.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eCinacalcet acts as a calcimimetic by increasing the sensitivity of the calcium-sensing receptor (CaSR) on parathyroid gland cells to extracellular calcium. This enhanced sensitivity causes a reduction in PTH secretion at lower serum calcium concentrations than would otherwise trigger suppression. The drug binds allosterically to the CaSR transmembrane domain, shifting its calcium-response curve to the left, thereby reducing PTH output without stimulating calcium absorption from the gut or bone resorption. The result is a coordinated reduction in PTH, serum calcium, and phosphorus levels.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eInitial dose: 30mg once daily with food or shortly after a meal.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eDose may be titrated up to 60mg, 90mg, 120mg, or 180mg every 2–4 weeks based on PTH levels.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eSwallow tablets whole; do not crush or chew.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eMonitor serum calcium, phosphorus, and PTH regularly during treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eDo not initiate if serum calcium is below the lower limit of normal.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eNausea and vomiting (most common)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eHypocalcemia and associated symptoms (muscle cramps, tingling)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eDiarrhea\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eMyalgia\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-left: .5in; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eDizziness\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 5.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eMimcipar 30mg is contraindicated in patients with serum calcium below normal limits (hypocalcemia) at the start of therapy. It should not be used in patients with known hypersensitivity to cinacalcet. Use with caution in patients with seizure disorders, as hypocalcemia can lower the seizure threshold. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 5.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eCinacalcet is a strong inhibitor of CYP2D6 and can significantly increase plasma concentrations of drugs metabolized by this enzyme, including tricyclic antidepressants, beta-blockers like metoprolol, and antipsychotics such as haloperidol. Co-administration with ketoconazole or other strong CYP3A4 inhibitors increases cinacalcet exposure substantially; dose adjustment may be required. Concomitant use with calcium or Vitamin D supplements may partially counteract the calcium-lowering effect. Patients on cardiac glycosides should be monitored carefully as electrolyte shifts may alter digoxin toxicity thresholds.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 5.0pt; line-height: normal;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eStore below 25°C in a dry, cool place. Protect from light and moisture. Keep in original packaging and out of reach of children. Do not use after the expiry date printed on the pack.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan lang=\"EN-GB\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"line-height: normal; margin: 12.0pt 0in 12.0pt 0in;\"\u003e\u003cspan lang=\"EN-GB\" style=\"font-size: 14.0pt;\"\u003eBuy Mimcipar 30mg Tablet online in Pakistan from Dawa Healthcare Pharmacy, a dependable platform for specialty medicines. If you want to check the latest Mimcipar 30mg tablet price in Pakistan, Dawa Healthcare offers clear pricing along with verified product details. You can conveniently order Mimcipar 30mg Tab online and enjoy fast, same-day delivery in Karachi, while orders from other cities are delivered through reliable courier services. Dawa Healthcare Pharmacy ensures the availability of genuine prescription medications with secure packaging. \u003c\/span\u003e\u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":51629420151067,"sku":"13573","price":1881.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_f98e782d-26ea-462a-974a-ae5cfa7a827f.jpg?v=1768417316"}],"url":"https:\/\/dawahealthcare.biz\/collections\/cinacalcethci.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}