{"title":"Brivaracetam50mg","description":null,"products":[{"product_id":"brivera-50mg-tab","title":"BRIVERA 50MG TAB","description":"\u003ch1\u003eBRIVERA 50MG TABLET ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 14.0pt;\"\u003eGENERIC: \u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; font-weight: normal;\"\u003eBrivaracetam 50mg\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 14.0pt;\"\u003eMANUFACTURER: \u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt; font-weight: normal;\"\u003eHelix Pharmaceuticals\u003c\/span\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eQUANTITY: \u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003ePack of 14 tablets\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eBrivera 50mg Tab is a third-generation anticonvulsant used as adjunctive therapy for partial-onset (focal) seizures with or without secondary generalization in adults, adolescents, and children aged 4 years and above. It may be used as monotherapy in adults when other antiepileptic drugs have not provided adequate seizure control.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eBrivaracetam is a high-affinity ligand for synaptic vesicle protein 2A (SV2A), a glycoprotein involved in regulating vesicle exocytosis at the synapse. By binding to SV2A, brivaracetam modulates neurotransmitter release and reduces neuronal hyperexcitability, thereby preventing the abnormal synchronized electrical discharges that cause seizures. It has 10-fold higher affinity for SV2A than levetiracetam, and also partially inhibits voltage-gated sodium channels.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eAdults and adolescents: starting dose 50mg twice daily; may be adjusted to 25mg or 100mg twice daily\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eChildren aged 4 to 16 years (20kg and above): dose based on weight; typically, 25mg to 100mg twice daily\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eTake with or without food; take regularly at the same times each day\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eIf switching from levetiracetam, no washout period is needed\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eDose adjustments required in patients with hepatic impairment\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 4.0pt 0in 3.0pt 0in;\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eCommon:\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eSomnolence (drowsiness), dizziness\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eFatigue, nausea\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eHeadache\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eIrritability or mood changes\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 4.0pt 0in 3.0pt 0in;\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eLess common:\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003ePsychiatric symptoms including aggression, agitation, anxiety, and depression\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eSuicidal ideation (all antiepileptics carry this risk — monitor closely)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eCoordination problems (ataxia, dysarthria)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eStevens-Johnson syndrome (rare skin reaction)\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eKnown hypersensitivity to brivaracetam or any excipient\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eUse with caution in patients with a history of psychiatric disorders\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eNot recommended during pregnancy unless the benefit clearly outweighs the risk\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eAbrupt withdrawal should be avoided; taper dose gradually\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eRifampicin, a strong CYP2C19 inducer, reduces brivaracetam exposure by approximately 45%; dose adjustment may be required. Brivaracetam inhibits CYP2C19 and may increase plasma levels of phenytoin and other CYP2C19 substrates. Co-administration with carbamazepine may increase carbamazepine-epoxide levels. No clinically relevant interactions with levetiracetam, lamotrigine, or valproate have been reported.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eStore Brivera 50mg tablets at room temperature below 30°C. Protect from moisture. Keep in original blister packaging. Store out of reach of children.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003e\u003cspan style=\"font-size: 14.0pt;\"\u003eBuy Brivera 50mg Tab online from Dawa Healthcare Pharmacy, a reliable source for antiepileptic medications in Pakistan. Check the Brivera 50mg Tab price in Pakistan and learn about Brivera 50mg Tab uses from our expert pharmacist team. Same-day delivery is available in Karachi. Dawa Healthcare Pharmacy delivers nationwide across Pakistan.\u003c\/span\u003e\u003cspan style=\"mso-bidi-font-size: 14.0pt;\"\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"HELIX PHARMA","offers":[{"title":"Strip","offer_id":47393308377371,"sku":"11911-3","price":567.0,"currency_code":"PKR","in_stock":true},{"title":"Pack","offer_id":47393308410139,"sku":"11911-107","price":1134.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/image-2023-04-15T152149.938_1_91c88d07-11fd-4076-9044-c41f6dbcd797.png?v=1704246127"}],"url":"https:\/\/dawahealthcare.biz\/collections\/brivaracetam50mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}