{"title":"Acyclovir500mg","description":null,"products":[{"product_id":"acyclovir-500mg-inj","title":"ACYCLOVIR 500MG INJ","description":"\u003cstrong\u003eGeneric Formula:  \u003c\/strong\u003eAcyclovir 500mg\u003cbr\u003e\u003cstrong\u003eManufacturer: \u003c\/strong\u003eABBOTT LABORATORIES PAKISTAN","brand":"ABBOTT LABORATORIES PAKISTAN","offers":[{"title":"Default Title","offer_id":47007068127515,"sku":"6825","price":1590.2,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/16547_8aaf7b71-a3b9-4326-be4c-76db57761f60.png?v=1721825734"},{"product_id":"aclovir-500mg-inj-genix","title":"ACLOVIR 500MG INJ (GENIX)","description":"\u003ch1\u003eACLOVIR 500MG INJECTION (GENIX) ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003eGENERIC: \u003c\/b\u003eAcyclovir Sodium 500mg (for Injection)\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003eMANUFACTURER:\u003c\/b\u003e Genix Pharma (Pvt) Ltd\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003eSingle vial for injection\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eINDICATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003eAclovir 500mg Inj is an antiviral agent indicated for the treatment of severe herpes simplex virus (HSV) infections including herpes simplex encephalitis, neonatal herpes, and immunocompromised patients with disseminated or severe mucocutaneous HSV infections. It is also indicated for the treatment of varicella-zoster (chickenpox and shingles) in immunocompromised patients, herpes zoster encephalitis, and in organ transplant recipients requiring antiviral prophylaxis against herpesvirus infections. Intravenous administration is required when oral therapy is not feasible or the infection is life-threatening.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eMECHANISM OF ACTION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003eAcyclovir is a synthetic purine nucleoside analogue that is selectively activated in virus-infected cells by viral thymidine kinase, which phosphorylates it to acyclovir monophosphate. Cellular enzymes then convert it to acyclovir triphosphate, which competitively inhibits viral DNA polymerase and is incorporated into the growing viral DNA chain, causing chain termination. Because viral thymidine kinase has much greater affinity for acyclovir than the host cell enzyme, the drug is selectively toxic to herpes-infected cells with minimal toxicity to normal host cells.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eDOSAGE AND ADMINISTRATION\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHerpes simplex encephalitis: 10mg\/kg every 8 hours by slow intravenous infusion over 1 hour, for 14 to 21 days\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSevere HSV in immunocompromised: 5mg\/kg every 8 hours for 7 to 14 days\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eVaricella-zoster in immunocompromised: 10mg\/kg every 8 hours for 7 to 10 days\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdminister by trained healthcare professionals only; dose reduction required in renal impairment\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eSIDE EFFECTS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"margin-bottom: 4.0pt;\" class=\"MsoNormal\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNausea and vomiting\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eHeadache\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eElevation of creatinine and urea (renal function monitoring required)\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eThrombophlebitis and inflammation at the injection site\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 4.0pt;\" class=\"MsoNormal\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eEncephalopathy (confusion, hallucinations, seizures) with high doses or in renal impairment\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAcute renal failure from crystalline nephropathy (maintain adequate hydration)\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eElevated liver enzymes\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAnemia, neutropenia, and thrombocytopenia with prolonged use\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eNOT RECOMMENDED IN\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eKnown hypersensitivity to acyclovir or valacyclovir\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAdminister slowly (over at least 1 hour) to reduce crystalluria and nephrotoxicity\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eEnsure adequate hydration before and during infusion\u003c\/p\u003e\n\u003cp style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\" class=\"MsoListParagraph\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDose adjustment mandatory in renal impairment\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eDRUG INTERACTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003eProbenecid reduces renal tubular secretion of acyclovir, increasing plasma levels; monitor for toxicity. Cimetidine also reduces acyclovir renal clearance. Concurrent nephrotoxic agents such as aminoglycosides, amphotericin B, and ciclosporin increase nephrotoxicity risk; monitor renal function closely. Acyclovir may increase plasma levels of mycophenolate in transplant recipients; monitor accordingly. Zidovudine combined with acyclovir may cause profound drowsiness and lethargy.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eSTORAGE INSTRUCTIONS\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003eStore unconstituted vials below 25°C away from direct light. Use reconstituted solution within 12 hours. Do not refrigerate reconstituted solution (crystals may form). Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 16.0pt; mso-bidi-font-size: 14.0pt;\"\u003eWHERE TO BUY\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003eYou can buy Aclovir 500mg injection (Genix) online from Dawa Healthcare Pharmacy at dawahealthcare.biz, one of Pakistan's most trusted pharmacies for authentic, pharmacist-verified medicines. Browse our product page to check the current Aclovir 500mg injection (Genix) price in pakistan, read detailed clinical information, and place your order from the comfort of your home. Our experienced pharmacist is always available to answer your questions about Aclovir 500mg injection (Genix) uses, correct dosage and suitability for your condition. Customers in Karachi enjoy same-day delivery on orders placed before the daily cutoff, while customers across Pakistan benefit from our nationwide courier service for safe and timely delivery to any city. You can also visit any of our Karachi branches in person or reach our dedicated WhatsApp support team for instant help with Aclovir 500mg injection (Genix) uses, pricing, prescriptions, and order placement.\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 6.0pt;\" class=\"MsoNormal\"\u003e \u003c\/p\u003e","brand":"GENIX PHARMA","offers":[{"title":"Pack","offer_id":49828296884507,"sku":"13308","price":1188.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/ACLOVIR500MGINJ_GENIX.webp?v=1775667272"}],"url":"https:\/\/dawahealthcare.biz\/collections\/acyclovir500mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}