{"title":"Acitretin25mg","description":null,"products":[{"product_id":"tigasor-25mg-cap-30s","title":"TIGASOR 25MG CAP 30S","description":"\u003ch1\u003eTIGASOR 25MG CAPSULE ONLINE AT BEST PRICE IN PAKISTAN\u003c\/h1\u003e\n\u003ch3\u003e\n\u003cb\u003eGENERIC: \u003c\/b\u003eAcitretin 25mg\u003c\/h3\u003e\n\u003ch3\u003e\n\u003cb\u003eMANUFACTURER:\u003c\/b\u003e Maxitech Pharma\u003c\/h3\u003e\n\u003ch3\u003e\u003cb\u003eQUANTITY:\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003ePack of 30 capsules\u003c\/p\u003e\n\u003ch2\u003eINDICATION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eTigasor 25mg Cap is a systemic retinoid indicated for the treatment of severe psoriasis that has not responded adequately to topical therapy or phototherapy. It is also indicated for other severe keratinization disorders including lamellar ichthyosis, Darier's disease, and palmoplantar keratoderma.\u003c\/p\u003e\n\u003ch2\u003eMECHANISM OF ACTION\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eAcitretin is the active metabolite of etretinate and a second-generation aromatic retinoid that binds to retinoic acid receptors (RARs) in the nucleus, modulating the transcription of genes involved in epidermal proliferation, differentiation, and inflammatory responses. In psoriasis, it normalizes the abnormally rapid keratinocyte proliferation and restores normal epidermal differentiation, reducing plaque formation, scale, and skin thickening. Acitretin also reduces inflammatory infiltration in the dermis and modulates immune cell activity in psoriatic skin. It is often used in combination with phototherapy for enhanced efficacy.\u003c\/p\u003e\n\u003ch2\u003eDOSAGE AND ADMINISTRATION\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eInitial dose: 25mg once daily with the main meal\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDose may be adjusted between 25mg and 50mg per day based on response and tolerability\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eTreatment course typically 3 to 6 months; reassess regularly\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAlways follow the dosage and monitoring schedule prescribed by your dermatologist\u003c\/p\u003e\n\u003ch2\u003eSIDE EFFECTS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eCommon:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eDry lips (cheilitis), dry skin, dry eyes, and dry nasal mucosa\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eElevated triglycerides and cholesterol (monitor lipids monthly initially)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eAlopecia (hair loss, usually reversible after stopping)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSkin fragility and increased photosensitivity\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 4.0pt;\"\u003e\u003cb\u003eLess common:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eTeratogenicity: causes severe fetal malformations; pregnancy must be absolutely prevented during treatment and for 3 years after stopping in females\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eElevated liver enzymes and hepatotoxicity (monitor LFTs regularly)\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eNight blindness and visual disturbances\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eMusculoskeletal pain and premature epiphyseal closure in children\u003c\/p\u003e\n\u003ch2\u003eNOT RECOMMENDED IN\u003c\/h2\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003ePregnancy or planned pregnancy within 3 years of stopping acitretin in females\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eWomen of childbearing potential not using two reliable contraceptive methods simultaneously\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eSevere hepatic or renal impairment\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"text-indent: -.25in; mso-list: l0 level1 lfo1; margin: 0in 0in 4.0pt .5in;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e•\u003cspan style=\"font: 7.0pt 'Times New Roman';\"\u003e      \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003eConcurrent use with methotrexate or vitamin A supplements; concurrent tetracyclines\u003c\/p\u003e\n\u003ch2\u003eDRUG INTERACTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eMethotrexate combined with acitretin markedly increases hepatotoxicity risk; concurrent use is contraindicated. Vitamin A supplements increase the risk of hypervitaminosis A toxicity. Tetracycline antibiotics combined with retinoids increase intracranial hypertension risk; avoid. Alcohol must be completely avoided during treatment and for 2 months after stopping (acitretin is converted back to etretinate in the presence of alcohol, greatly extending teratogenic risk). Phenytoin protein binding may be reduced by acitretin.\u003c\/p\u003e\n\u003ch2\u003eSTORAGE INSTRUCTIONS\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eStore below 25°C in a dry place away from direct sunlight. Keep in original packaging. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eWHERE TO BUY\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 6.0pt;\"\u003eYou can buy Tigasor 25mg cap 30S online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Tigasor 25mg cap price in pakistan and learn about Tigasor 25mg capsule uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Tigasor 25mg capsule uses, pricing, and order placement.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Dawa Healthcare","offers":[{"title":"Pack","offer_id":51629446168859,"sku":"14829","price":2275.5,"currency_code":"PKR","in_stock":true},{"title":"Strip","offer_id":51629446201627,"sku":"14829-1","price":758.5,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/8041\/1931\/files\/placeholder_720x_84eb0f6e-ff25-4304-bd2d-6b6118c52792.jpg?v=1768417763"}],"url":"https:\/\/dawahealthcare.biz\/collections\/acitretin25mg.oembed","provider":"Dawa Healthcare","version":"1.0","type":"link"}